Bibliographic Details
| Title: |
Effect of 5-year continuous positive airway pressure treatment on MMPs and TIMPs: implications for OSA comorbidities. |
| Authors: |
Simon, Beatrix1,2, Barta, Imre1, Gabor, Bettina2, Paska, Csilla1, Boszormenyi Nagy, Gyorgy2, Vizi, Eva2, Antus, Balazs1,2 antusb@hotmail.com |
| Source: |
Scientific Reports. 5/25/2020, Vol. 10 Issue 1, p1-7. 7p. |
| Subject Terms: |
*CONTINUOUS positive airway pressure, *SLEEP apnea syndromes, *MATRIX metalloproteinases, *TISSUE inhibitors of metalloproteinases, *CARDIOVASCULAR diseases |
| Abstract: |
Continuous positive airway pressure (CPAP) treatment results in nearly complete remission of symptoms of obstructive sleep apnoea (OSA); however, its effect on OSA comorbidities including cardiovascular diseases remains contradictory. Here we investigated the short- and long-term effect of CPAP treatment on matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in patients with severe OSA. Serum levels of 7 MMPs and 3 TIMPs were followed in OSA patients (n = 28) with an apnoea-hypopnoea index of ≥30 events/h at the time of diagnosis and at control visits (2 months, 6 months and 5 years) after initiation of fixed-pressure CPAP treatment. The first few months of CPAP therapy resulted in significant decrease of MMP-8 and MMP-9 levels (MMP-8: 146 (79–237) vs. 287 (170–560) pg/mL; MMP-9: 10.1 (7.1–14.1) vs. 12.7 (10.4–15.6) ng/mL, p < 0.05 for each at 2 months), while the rest of the panel remained unchanged as compared to baseline values. In contrast, at 5 years, despite of uninterrupted CPAP treatment and excellent adherence the levels of MMP-8, MMP-9 and TIMPs significantly increased (p < 0.05). Our data suggest that initiation of CPAP therapy leads to a decrease in the level of key MMPs in the short-term; however, this effect is not sustained over the long-term. [ABSTRACT FROM AUTHOR] |
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