Bibliographic Details
| Title: |
FDG-PET SCAN IN LOCAL FOLLOW-UP OF IRRADIATED HEAD AND NECK SQUAMOUS CELL CARCINOMAS. |
| Authors: |
Conessa, Claude1, Foehrenbach, Herve2, Hervé, Stephane1, Poncet, Jean-Luc1 |
| Source: |
Annals of Otology, Rhinology & Laryngology. Aug2004, Vol. 113 Issue 8, p628-635. 8p. 2 Diagrams, 1 Chart. |
| Subject Terms: |
*POSITRON emission tomography, *SQUAMOUS cell carcinoma, *CANCER, *TOMOGRAPHY, *HEAD & neck cancer treatment |
| Abstract: |
We performed a prospective study to assess the value of positron emission tomography (PET) with 2-[18F)-fluoro-2-deoxy-D-glucose (FDG) in the prediction of local control in irradiated head and neck squamous cell carcinomas (HNSCCs). Forty-two patients with irradiated HNSCCs underwent 49 FDG-PET scans between 3 and 6 months after the end of radiotherapy. The mean follow-up time after the first FDG-PET scan was 17 months. The result of the FDG-PET scan was true-positive in 6 patients, false- positive in 7 patients, and true-negative in 29 patients. The sensitivity, specificity, positive predictive value, and negative predictive value of FDG-PET scanning were 100%, 81%, 46%, and 100%, respectively. We conclude that FDG-PET scanning is useful for prediction of therapy outcome in irradiated HNSCCs. No biopsy is needed for at least 1 year if an FDG-PET scan is negative. If the scan is positive and the biopsy is negative, decreased FDG uptake measured in a follow-up scan indicates that a local recurrence is unlikely. [ABSTRACT FROM AUTHOR] |
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| Database: |
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