Bibliographic Details
| Title: |
ASTMUL BRONŞIC ALERGIC LA COPII - EVOLUŢIE NATURALĂ , SUBSTRAT INFLAMATOR. |
| Alternate Title: |
Allergic bronchial asthma in childhood-natural history, the role of chronic inflammation. |
| Authors: |
Borta, Simona Maria1,2 simoborta@yahoo.com, Donath-Miklos, Imola3, Popeţiu, Romana Olivia1,2, Puşchiţă, Maria1,2 |
| Source: |
Romanian Medical Journal. 2019, Vol. 66 Issue 3, p216-220. 5p. 3 Diagrams, 2 Charts. |
| Subject Terms: |
*FACTORS of production, *IMMUNE system, *ASTHMA, *ASTHMATICS, *BRONCHOCONSTRICTION, *EPITHELIUM |
| Abstract (English): |
The inflammatory response in the airways of patients with asthma involves the interaction between the respiratory epithelium, the innate immune system and the adaptive immunity, which initiates and maintains the chronic inflammatory response. Environmental factors in interaction with local factors induce the production of proinflammatory mediators in the airway epithelium and then activate the proinflammatory cells. The pro-inflammatory cells infiltrate the lungs and release other mediators, which accentuate the inflammatory response at this level, thus achieving a vicious circle of inflammation. This process causes bronchoconstriction and epithelial injury, which results in airway remodeling. [ABSTRACT FROM AUTHOR] |
| Abstract (Romanian): |
Iniţierea şi întreţinerea răspunsului inflamator la nivelul căilor respiratorii la pacienţii cu astm bronşic implică interacţiunea între epiteliul respirator, sistemul imunitar înnăscut şi cel adaptiv. Factorii de mediu şi factorii locali induc producţia de mediatori proinflamatori la nivelul epiteliului căilor respiratorii, activând apoi celulele proinflamatorii. Celulele proinflamatorii infiltrează plămânii şi eliberează alţi mediatori, care accentuează răspunsul inflamator la acest nivel, astfel realizând un cerc vicios al inflamaţiei. Acest proces cauzează bronhoconstricţie şi leziuni epiteliale, care determină remodelarea căilor respiratorii. [ABSTRACT FROM AUTHOR] |
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| Database: |
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