| Title: |
In vitro antidiabetic, anti-inflammatory and antioxidant potential of the ethanol extract of Uromastyx hardwickii skin. |
| Authors: |
Shams, Waqas Ahmad1, Rehman, Gauhar1, Onoja, Samuel Okwudili2 samonreal@yahoo.com, Ali, Abid1, Khan, Khurshaid1, Niaz, Sadaf1 |
| Source: |
Tropical Journal of Pharmaceutical Research. Oct2019, Vol. 18 Issue 10, p2109-2115. 7p. |
| Subject Terms: |
*ERYTHROCYTES, *HYDROGEN peroxide, *SKIN, *ANTIOXIDANTS, *ETHANOL |
| Abstract: |
Purpose: To evaluate the in vitro antidiabetic, anti-inflammatory and antioxidant potential of the ethanol extract of Uromastyx hardwickii Skin (UHSEE). Methods: The in vitro effects of UHSEE at various concentrations (10 - 250 μg/mL) on the activities of α-amylase, α-glucosidase and glucose uptake by yeast cells were used to evaluate its antidiabetic potential. Nitric oxide (NO), 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydrogen peroxide inhibitory assay were employed to determine its antioxidant effects, while the anti-inflammatory effects were evaluated using human red blood cell (HRBC) membrane stabilization assay. Results: UHSEE inhibited α-amylase and α-glucosidase enzymes but increased glucose uptake by yeast cells in a concentration-dependent manner (p < 0.05). It also inhibited NO, DPPH, hydrogen peroxide and HRBC hemolysis in a concentration-dependent manner (p < 0.05). Conclusion: Uromastyx hardwickii skin exhibits promising good antidiabetic, antioxidant and antiinflammatory properties in vitro. However, its true potentials in this regard needs to be evaluted in vivo. [ABSTRACT FROM AUTHOR] |
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| Database: |
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