Bibliographic Details
| Title: |
Cross-Reaction, Enhancement, and Neutralization Activity of Dengue Virus Antibodies against Zika Virus: A Study in the Mexican Population. |
| Authors: |
Montecillo-Aguado, Mayra R.1, Montes-Gómez, Alfredo E.1, García-Cordero, Julio1, Corzo-Gómez, Josselin1, Vivanco-Cid, Héctor2, Mellado-Sánchez, Gabriela3, Muñoz-Medina, J. Esteban4, Gutiérrez-Castañeda, Benito5, Santos-Argumedo, Leopoldo1, González-Bonilla, César6, Cedillo-Barrón, Leticia1 |
| Source: |
Journal of Immunology Research. 9/2/2019, p1-14. 14p. 1 Color Photograph, 3 Diagrams, 2 Charts, 3 Graphs. |
| Subject Terms: |
*DENGUE viruses, *ZIKA virus, *DENGUE hemorrhagic fever, *DENGUE, *CROSS reactions (Immunology) |
| Geographic Terms: |
MEXICO |
| Abstract: |
Zika virus (ZIKV), an emerging mosquito-borne flavivirus, has quickly spread in many regions around the world where dengue virus (DENV) is endemic. This represents a major health concern, given the high homology between these two viruses, which can result in cross-reactivity. The aim of this study was to determine the cross-reacting antibody response of the IgM and IgG classes against the recombinant envelope protein of ZIKV (rE-ZIKV) in sera from patients with acute-phase infection of different clinical forms of dengue, i.e., dengue fever (DF) and dengue hemorrhagic fever (DHF) (before the arrival of ZIKV in Mexico 2010), as well as acute-phase sera of ZIKV patients, together with the implications in neutralization and antibody-dependent enhancement. Differences in IgM responses were observed in a number of DF and DHF patients whose sera cross-reacted with the rE-ZIK antigen, with 42% recognition between acute-phase DHF and ZIKV but 27% recognition between DF and ZIKV. Regarding IgG antibodies, 71.5% from the DF group showed cross-reactivity to rE-ZIKV in contrast with 50% and only 25% of DHF and ZIKV serum samples, respectively, which specifically recognized the homologous antigen. The DHF group showed more enhancement of ZIKV infection of FCRγ-expressing cells compared to the DF group. Furthermore, the DHF group also showed a higher cross-neutralizing ability than that of DF. This is the first report where DF and DHF serum samples were evaluated for cross-reactivity against Zika protein and ZIKV. Furthermore, DENV serum samples cross-protect against ZIKV through neutralizing antibodies but at the same time mediate antibody-dependent enhancement in the sequential ZIKV infection. [ABSTRACT FROM AUTHOR] |
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Copyright of Journal of Immunology Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
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