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RNA/DNA structures recognized by RNase H2.

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Title: RNA/DNA structures recognized by RNase H2.
Authors: Kojima, Kenji1 (AUTHOR), Baba, Misato1 (AUTHOR), Tsukiashi, Motoki1 (AUTHOR), Nishimura, Takuto1 (AUTHOR), Yasukawa, Kiyoshi1 (AUTHOR) yasukawa@kais.kyoto-u.ac.jp
Source: Briefings in Functional Genomics. May2019, Vol. 18 Issue 3, p169-173. 5p.
Subject Terms: *RIBONUCLEASE H, *RIBONUCLEOSIDE diphosphate reductase, *DOUBLE-strand DNA breaks, *RNA, *DNA repair, *DNA structure, *SINGLE-stranded DNA
Abstract: Ribonuclease H (RNase H) [EC 3.1.26.4] is an enzyme that specifically degrades RNA from RNA/DNA hybrids. Since its discovery in 1969, the enzyme has been extensively studied for its catalytic mechanism and physiological role. RNase H has been classified into two major families, Type 1 and Type 2. Type 1 enzymes are designated RNase HI in prokaryotes and RNase H1 in eukaryotes, while Type 2 enzymes are designated RNase HII in prokaryotes and RNase H2 in eukaryotes. Type 2 enzymes are able to cleave the 5′-phosphodiester bond of one ribonucleotide embedded in a DNA double strand. Recent studies have shown that RNase H2 is involved in excision of a single ribonucleotide embedded in genomic DNA and removal of an R-loop formed in cells. It is also involved in double-strand break of DNA and its repair. In this review, we aim to outline the structures recognized by RNase H2. [ABSTRACT FROM AUTHOR]
Copyright of Briefings in Functional Genomics is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: RNA/DNA structures recognized by RNase H2.
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  Data: <searchLink fieldCode="AR" term="%22Kojima%2C+Kenji%22">Kojima, Kenji</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Baba%2C+Misato%22">Baba, Misato</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tsukiashi%2C+Motoki%22">Tsukiashi, Motoki</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nishimura%2C+Takuto%22">Nishimura, Takuto</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yasukawa%2C+Kiyoshi%22">Yasukawa, Kiyoshi</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> yasukawa@kais.kyoto-u.ac.jp</i>
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  Data: <searchLink fieldCode="JN" term="%22Briefings+in+Functional+Genomics%22">Briefings in Functional Genomics</searchLink>. May2019, Vol. 18 Issue 3, p169-173. 5p.
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  Data: *<searchLink fieldCode="DE" term="%22RIBONUCLEASE+H%22">RIBONUCLEASE H</searchLink><br />*<searchLink fieldCode="DE" term="%22RIBONUCLEOSIDE+diphosphate+reductase%22">RIBONUCLEOSIDE diphosphate reductase</searchLink><br />*<searchLink fieldCode="DE" term="%22DOUBLE-strand+DNA+breaks%22">DOUBLE-strand DNA breaks</searchLink><br />*<searchLink fieldCode="DE" term="%22RNA%22">RNA</searchLink><br />*<searchLink fieldCode="DE" term="%22DNA+repair%22">DNA repair</searchLink><br />*<searchLink fieldCode="DE" term="%22DNA+structure%22">DNA structure</searchLink><br />*<searchLink fieldCode="DE" term="%22SINGLE-stranded+DNA%22">SINGLE-stranded DNA</searchLink>
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  Data: Ribonuclease H (RNase H) [EC 3.1.26.4] is an enzyme that specifically degrades RNA from RNA/DNA hybrids. Since its discovery in 1969, the enzyme has been extensively studied for its catalytic mechanism and physiological role. RNase H has been classified into two major families, Type 1 and Type 2. Type 1 enzymes are designated RNase HI in prokaryotes and RNase H1 in eukaryotes, while Type 2 enzymes are designated RNase HII in prokaryotes and RNase H2 in eukaryotes. Type 2 enzymes are able to cleave the 5′-phosphodiester bond of one ribonucleotide embedded in a DNA double strand. Recent studies have shown that RNase H2 is involved in excision of a single ribonucleotide embedded in genomic DNA and removal of an R-loop formed in cells. It is also involved in double-strand break of DNA and its repair. In this review, we aim to outline the structures recognized by RNase H2. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Briefings in Functional Genomics is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1093/bfgp/ely024
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        Text: English
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        Type: general
      – SubjectFull: RIBONUCLEOSIDE diphosphate reductase
        Type: general
      – SubjectFull: DOUBLE-strand DNA breaks
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      – SubjectFull: DNA structure
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      – SubjectFull: SINGLE-stranded DNA
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      – TitleFull: RNA/DNA structures recognized by RNase H2.
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            NameFull: Kojima, Kenji
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            NameFull: Baba, Misato
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            NameFull: Tsukiashi, Motoki
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            NameFull: Nishimura, Takuto
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              M: 05
              Text: May2019
              Type: published
              Y: 2019
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