Bibliographic Details
Title: |
SHIV.CH505-infected infant and adult rhesus macaques exhibit similar HIV. |
Authors: |
Nelson, Ashley N.1, Goswami, Ria1, Dennis, Maria1, Joshua Tu1, Mangan, Riley J.1, Saha, Pooja T.2, Cain, Derek W.1, Curtis, Alan D.2, Xiaoying Shen1, Shaw, George M.3, Bar, Katharine3, Hudgens, Michael2, Pollara, Justin1, De Paris, Kristina4, Van Rompay, Koen K. A.5 sallie.permar@duke.edu, Permar, Sallie R.1 |
Source: |
Journal of Virology. Aug2019, Vol. 93 Issue 15, p1-44. 59p. |
Subject Terms: |
*HIV, *RHESUS monkeys, *T helper cells, *HIV antibodies, *HUMORAL immunity, *INFANTS |
Abstract: |
Global elimination of pediatric human immunodeficiency virus (HIV) infections will require the development of novel immune-based approaches, and understanding infant immunity to HIV is critical to guide the rational design of these intervention strategies. Despite their immunological immaturity, chronically HIV-infected children develop broadly neutralizing antibodies (bnAbs) more frequently and earlier than adults do. However, the ontogeny of humoral responses during acute HIV infection is poorly defined in infants and challenging to study in human cohorts due to the presence of maternal antibodies. To further our understanding of age-related differences in the development of HIV-specific immunity during acute infection, we evaluated the generation of virus-specific humoral immune responses in infant (n=6) and adult (n=12) rhesus macaques (RMs) infected with a transmitted/founder (T/F) simian-human immunodeficiency virus (SHIV) (SHIV.C.CH505 [CH505]). The plasma HIV envelope-specific IgG antibody kinetics were similar in SHIV-infected infant and adult RMs, with no significant differences in the magnitude or breadth of these responses. Interestingly, autologous tier 2 virus neutralization responses also developed with similar frequencies and kinetics in infant and adult RMs, despite infants exhibiting significantly higher follicular T helper cell (Tfh) and germinal center B cell frequencies than adults. Finally, we show that plasma viral load was the strongest predictor of the development of autologous virus neutralization in both age groups. Our results indicate that the humoral immune response to SHIV infection develops with similar kinetics among infant and adult RMs, suggesting that the early-life immune system is equipped to respond to HIV-1 and promote the production of neutralizing HIV antibodies. [ABSTRACT FROM AUTHOR] |
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Database: |
Academic Search Complete |