Bibliographic Details
| Title: |
Angiotensin 1-7 Administration Increases Renal Blood Flow in the Absence of Bradykinin B2 Receptor in Ovariectomized Estradiol Treated Rats: The Role of Mas Receptor. |
| Authors: |
Saberi, Shadan1,2, Dehghani, Aghdas1,3, Nematbakhsh, Mehdi1,4,5 nematbakhsh@med.mui.ac.ir |
| Source: |
Acta Medica Iranica. 2019, Vol. 57 Issue 2, p103-109. 7p. |
| Subject Terms: |
*BRADYKININ receptors, *BLOOD flow, *ESTRADIOL, *ANGIOTENSINS, *VASCULAR resistance |
| Geographic Terms: |
CAIRO (Egypt) |
| Abstract: |
Renin angiotensin (RAS), kallikrein kinin (KKS), and sex hormonal systems demonstrate a complex contribution in kidney circulation. This study was designed to investigate the role of angiotensin 1-7 (Ang 1-7) receptor (MasR) and of bradykinin B2 receptor (B2R) in renal blood flow (RBF) response to Ang 1-7 infusion in ovariectomized estradiol treated rats. The ovariectomized rats received intramuscular vehicle (group 1, OV) or estradiol valerate (500 µg/Kg/week) (group 2, OVE) for two weeks. Then each group was divided into two subgroups subjected to receive B2R antagonist (HOE-140, subgroup A), or MasR antagonist (A779) plus HOE-140 (subgroup B). RBF and renal vascular resistance (RVR) responses to graded Ang 1-7 infusion were determined. In condition of B2R alone blocking, RBF response to Ang 1-7 in OVE group was significantly greater than that of OV group (P=0.05), however this response difference was failed by coblockades of MasR and B2R. Estradiol could promote RBF response to graded Ang 1-7 infusion in the absence of B2R alone, however when both receptors (MasR and B2R) were blocked the role of estradiol was limited. [ABSTRACT FROM AUTHOR] |
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| Database: |
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