Bibliographic Details
| Title: |
Ergostane steroids from the ethanol extract of Dysoxylum mollissimum. |
| Authors: |
Huang, Xiao-Yun1,2, Liu, Zhi-Ming2,3, Shi, Hui-Ping1, Hu, Jiang2, Han, Dun-Xin4 13356956832@163.com |
| Source: |
Journal of Asian Natural Products Research. Feb2019, Vol. 21 Issue 2, p103-108. 6p. |
| Subject Terms: |
*ANTI-inflammatory agents, *BARK, *ENZYME inhibitors, *ETHANOL, *LEGUMES, *MASS spectrometry, *MOLECULAR structure, *NONSTEROIDAL anti-inflammatory agents, *NUCLEAR magnetic resonance spectroscopy, *STEROIDS, *PLANT extracts, *CYCLOOXYGENASE 2, *PHARMACODYNAMICS |
| Geographic Terms: |
CHINA |
| Abstract: |
Three new ergostane steroids, 7α-acetoxyl-ergosta-5,24(28)-diene-3β,4β,20S-triol (1), 7α-acetoxyl-ergosta-5,24(28)-diene-3β,4β-diol (2), and 7α-acetoxyl-ergosta-5,24(28)-3β-ol (3) were isolated from the ethanol extract of stem bark of Dysoxylum mollissimum BI. Structural elucidation of all the compounds was performed by spectral methods such as 1D and 2D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. All the isolated steroids were in vitro evaluated for their anti-inflammatory activity against COX-1 and COX-2. As a result, steroids 1-3 exhibited modest selective inhibition for COX-1 (>60%). [ABSTRACT FROM AUTHOR] |
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