Bibliographic Details
| Title: |
Cognitive Training and Transcranial Direct Current Stimulation for Mild Cognitive Impairment in Parkinson’s Disease: A Randomized Controlled Trial. |
| Authors: |
Lawrence, Blake J.1,2,3,4, Gasson, Natalie1,2, Johnson, Andrew R.1,2, Booth, Leon1,2, Loftus, Andrea M.1,2 |
| Source: |
Parkinson's Disease (20420080). 3/26/2018, p1-12. 12p. |
| Subject Terms: |
*PARKINSON'S disease treatment, *COGNITION disorders treatment, *ATTENTION, *COGNITIVE therapy, *LANGUAGE & languages, *HEALTH outcome assessment, *QUALITY of life, *SHORT-term memory, *ACTIVITIES of daily living, *RANDOMIZED controlled trials, *TREATMENT effectiveness, *EXECUTIVE function, *TRANSCRANIAL direct current stimulation |
| Abstract: |
This study examined whether standard cognitive training, tailored cognitive training, transcranial direct current stimulation (tDCS), standard cognitive training + tDCS, or tailored cognitive training + tDCS improved cognitive function and functional outcomes in participants with PD and mild cognitive impairment (PD-MCI). Forty-two participants with PD-MCI were randomized to one of six groups: (1) standard cognitive training, (2) tailored cognitive training, (3) tDCS, (4) standard cognitive training + tDCS, (5) tailored cognitive training + tDCS, or (6) a control group. Interventions lasted 4 weeks, with cognitive and functional outcomes measured at baseline, post-intervention, and follow-up. The trial was registered with the Australian New Zealand Clinical Trials Registry (ANZCTR: 12614001039673). While controlling for moderator variables, Generalized Linear Mixed Models (GLMMs) showed that when compared to the control group, the intervention groups demonstrated variable statistically significant improvements across executive function, attention/working memory, memory, language, activities of daily living (ADL), and quality of life (QOL; Hedge’s g range = 0.01 to 1.75). More outcomes improved for the groups that received standard or tailored cognitive training combined with tDCS. Participants with PD-MCI receiving cognitive training (standard or tailored) or tDCS demonstrated significant improvements on cognitive and functional outcomes, and combining these interventions provided greater therapeutic effects. [ABSTRACT FROM AUTHOR] |
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