| Title: |
(±)-Sativamides A and B, Two Pairs of Racemic Nor-Lignanamide Enantiomers from the Fruits of Cannabis sativa. |
| Authors: |
Guo-Yuan Zhu1 gyzhu@must.edu.mo, Ji Yang1, Xiao-Jun Yao1, Xing Yang2, Jing Fu1, Xin Liu1, Li-Ping Bai1, Liang Liu1, Zhi-Hong Jiang1 zhjiang@must.edu.mo |
| Source: |
Journal of Organic Chemistry. 2/16/2018, Vol. 83 Issue 4, p2376-2381. 6p. |
| Abstract: |
(±)-Sativamides A (1) and B (2), two pairs of nor-lignanamide enantiomers featuring a unique benzo-angular triquinane skeleton, were isolated from the fruits of Cannabis sativa (hemp seed). Their structures were elucidated by detailed spectroscopic analysis and ECD calculations. The resolution of (+)- and (-)-sativamides A and B were achieved by chiral HPLC. Pretreatment of neuroblastoma cells with 1 and 2 significantly reduced the endoplasmic reticulum (ER) stress-induced cytotoxicity. [ABSTRACT FROM AUTHOR] |
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| Database: |
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