Bibliographic Details
| Title: |
RELATIONSHIP BETWEEN ETANERCEPT AND THYROID FUNCTION IN PATIENTS WITH PSORIASIS VULGARIS. |
| Authors: |
ROMAN, IULIA IOANA1 iuliaroman09@gmail.com, MOCAN, TEODORA2, ORASAN, MEDA-SANDRA2, JIANU, ELENA MIHAELA3, SFRANGEU, CARMEN-ANGELA2, ORASAN, REMUS-IOAN1 |
| Source: |
Clujul Medical. 2018, Vol. 91 Issue 1, p42-47. 6p. |
| Subject Terms: |
*ETANERCEPT, *PSORIASIS treatment, *THYROID gland function tests, *THERAPEUTICS |
| Abstract: |
Background and aim. Psoriasis vulgaris, a chronic inflammatory skin disease, requires a long term medication, in order to avoid relapsing episodes. TNFalpha, one of the targeted molecule in psoriasis therapy, seems to be also involved in thyroid disorders etiopathogenesis. The aim of this study was to evaluate the relationship between anti TNF-alpha therapy and thyroid parameters: serum level of triiodothyronine (T3), free thyroxine (FT4), thyroid-stimulating hormone (TSH) and antithyroidperoxidase antibody (AbTPO) in psoriasis treated population. Methods. The study was performed on 44 patients with psoriasis vulgaris (20 patients under antiTNF-alpha treatment (etanercept), 24 patients with no previous systemic therapy). Serum concentrations of hormones, AbAntiTPO and TNF-alpha were measured and a thyroid ultrasonographic evaluation was performed for each patient. Results. The mean serum level of FT4 was significantly higher in patients with no systemic treatment (p<0.05). The patients treated with etanercept had a significantly higher level of TNF-alpha (p<0.05). No significant difference was observed for the other evaluated parameters. Also, we found a significant negative correlation between TNF-alpha and TSH levels (r=-0.366, p=0.015). Conclusions. We only found that the mean level of FT4 was significantly higher in patients with no systemic treatment. Also, a negative strong correlation was seen between serum level of TSH and TNF-alpha. Based on our data, comparison with other anti TNF-alpha therapies might be of interest in future studies. [ABSTRACT FROM AUTHOR] |
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