Bibliographic Details
| Title: |
Host Cell Restriction Factors that Limit Influenza A Infection. |
| Authors: |
Villalón-Letelier, Fernando1 fvillalon@student.unimelb.edu.au, Brooks, Andrew G.1 agbrooks@unimelb.edu.au, Saunders, Philippa M.1 philippa.saunders@unimelb.edu.au, Londrigan, Sarah L.1 sarahll@unimelb.edu.au, Reading, Patrick C.1,2 preading@unimelb.edu.au; |
| Source: |
Viruses (1999-4915). Dec2017, Vol. 9 Issue 12, p376. 18p. |
| Subject Terms: |
*INFLUENZA A virus, H1N1 subtype, *THERAPEUTIC use of interferons, *ECTOPIC hormones, *GENE silencing, *ANTIVIRAL agents, *THERAPEUTICS |
| Abstract: |
Viral infection of different cell types induces a unique spectrum of host defence genes, including interferon-stimulated genes (ISGs) and genes encoding other proteins with antiviral potential. Although hundreds of ISGs have been described, the vast majority have not been functionally characterised. Cellular proteins with putative antiviral activity (hereafter referred to as "restriction factors") can target various steps in the virus life-cycle. In the context of influenza virus infection, restriction factors have been described that target virus entry, genomic replication, translation and virus release. Genome wide analyses, in combination with ectopic overexpression and/or gene silencing studies, have accelerated the identification of restriction factors that are active against influenza and other viruses, as well as providing important insights regarding mechanisms of antiviral activity. Herein, we review current knowledge regarding restriction factors that mediate anti-influenza virus activity and consider the viral countermeasures that are known to limit their impact. Moreover, we consider the strengths and limitations of experimental approaches to study restriction factors, discrepancies between in vitro and in vivo studies, and the potential to exploit restriction factors to limit disease caused by influenza and other respiratory viruses. [ABSTRACT FROM AUTHOR] |
|
Copyright of Viruses (1999-4915) is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Complete |
