Bibliographic Details
| Title: |
Epidemiologic study of major complications in adolescent and adult patients with thalassemia in Northeastern Thailand: the E-SAAN study phase I. |
| Authors: |
Teawtrakul, Nattiya1 (AUTHOR) nattiya@kku.ac.th, Jetsrisuparb, Arunee2 (AUTHOR), Pongudom, Saranya3 (AUTHOR), Sirijerachai, Chittima1 (AUTHOR), Chansung, Kanchana1 (AUTHOR), Wanitpongpun, Chinadol1 (AUTHOR), Fucharoen, Supan4 (AUTHOR) |
| Source: |
Hematology. Jan2018, Vol. 23 Issue 1, p55-60. 6p. |
| Subject Terms: |
*THALASSEMIA diagnosis, *EPIDEMIOLOGY, *DISEASE complications, DISEASES in adults |
| Geographic Terms: |
NORTHEASTERN Thailand |
| Abstract: |
Introduction:Thalassemia-related complications are one of the main factors that increase morbidity and mortality in aging patients with thalassemia. This study was aimed to report the prevalence and clinical risk factors for the complications in thalassemia. Methods:A multi-center prospective cohort study was conducted in patients with thalassemia aged ≥10 years old. Thalassemia-related complications were heart failure, pulmonary hypertension, extramedullary hematopoiesis, endocrine disorders, infections, thrombosis and leg ulcers. The clinical parameters significantly associated with the complications were analyzed by logistic regression methods. Results:The prevalence of thalassemia-related complications was 60.5% in patients with transfusion-dependent thalassemia (TDT) and 43% in patients with non-transfusion-dependent thalassemia (NTDT). Splenectomy was statistically associated with complications in both TDT and NTDT patients (adjusted odds ratio (AOR) = 7.4,p-value = 0.0001 and AOR = 2.6,p-value = 0.001). Age ≥50 years old (AOR = 2.9,p-value = 0.04) and female gender (AOR = 0.5,p-value = 0.03) were statistically associated with the complications in patients with NTDT. Conclusion:Nearly half of the patients in this cohort had disease-related complications. Splenectomy and advanced age were important factors for complication involvement. Early screening for the complications may reduce the morbidity and mortality in patients with thalassemia. [ABSTRACT FROM PUBLISHER] |
|
Copyright of Hematology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Complete |
|
Full text is not displayed to guests. |
Login for full access.
|
