Bibliographic Details
| Title: |
Hepatitis C and Its Relation to B-Cell Lymphoma. |
| Authors: |
Virone, Alexandre1, Saadoun, David1,2,3,4, Cacoub, Patrice1,2,3,4 patrice.cacoub@aphp.fr |
| Source: |
Lymphoma & Chronic Lymphocytic Leukemias. 2017, Issue 7, p1-6. 6p. |
| Subject Terms: |
*HEPATITIS C virus, *HEPATITIS C, *DISEASE prevalence, *CRYOGLOBULINEMIA, *PROTO-oncogenes, *INSULIN resistance |
| Abstract: |
Hepatitis C virus (HCV) infection is a global health concern, with millions of people chronically infected. The course of this chronic disease may lead to lymphoproliferative disorders ranging from benign mixed cryoglobulinemia to malignant non-Hodgkin lymphoma (NHL). In this article, we reviewed the current knowledge of the different pathologic mechanisms involved in the occurrence of HCV-related lymphoproliferative diseases. Hepatitis C virus directly or indirectly causes different steps of progressive alterations. A chronic antigenic stimulation will select a B-cell clone that will gain immortality via alterations in coding DNA in proto-oncogenes and tumour-suppressor regions. The main challenge in the treatment of HCV-induced NHL is to obtain a sustained virologic response before HCV induced irreversible damages leading to everlasting cell survival. The new interferon-free therapies introduce a new era of management of HCV-NHL, with recent published data to be promising. Nevertheless, further studies are required to assess the safety of those drugs, particularly in association with chemotherapy. [ABSTRACT FROM AUTHOR] |
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| Database: |
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