| Title: |
Total Synthesis of Kehokorins A-E, Cytotoxic p-Terphenyls. |
| Authors: |
Shunya Takahashi1 shunyat@riken.jp, Yasuaki Suda1,2, Takemichi Nakamura1, Koji Matsuoka2, Hiroyuki Koshino1 |
| Source: |
Journal of Organic Chemistry. 3/17/2017, Vol. 82 Issue 6, p3159-3166. 8p. |
| Abstract: |
This paper describes a general method for the synthesis of kehokorins A-E, novel cytotoxic p-terphenyls. 2,4,6-Trihydroxybenzaldehyde served as a common building block for preparation of the central aromatic ring. Construction of their p-terphenyl skeletons was achieved by a stepwise Suzuki-Miyaura coupling, whereas the phenyldibenzofuran moiety was built up by an intramolecular Ullmann reaction. Introduction of an l-rhamnose residue into partly protected kehokorin B was performed by the trichloroacetimidate method. [ABSTRACT FROM AUTHOR] |
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| Database: |
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