Academic Journal
View in EDS

Clinical outcomes and prognostic factors of resected pancreatic neuroendocrine neoplasms: A single-center experience in China.

Bibliographic Details
Title: Clinical outcomes and prognostic factors of resected pancreatic neuroendocrine neoplasms: A single-center experience in China.
Authors: KAIZHOU JIN1,2,3, GUOPEI LUO1,2,3, JIN XU1,2,3, BO ZHANG1,2,3, CHEN LIU1,2,3, SHUNRONG JI1,2,3, LIANG LIU1,2,3, JIANG LONG1,2,3, QUANXING NI1,2,3, XIANJUN YU1,2,3 yuxianjun@fudanpci.org
Source: Oncology Letters. May2017, Vol. 13 Issue 5, p3163-3168. 6p.
Subject Terms: *NEUROENDOCRINE tumors, *PANCREATIC diseases, *PROGNOSIS, *TUMOR grading, *MULTIVARIATE analysis
Abstract: The aim of the present study was to investigate the clinical, pathological and prognostic characteristics of Chinese patients with resected pancreatic neuroendocrine neoplasms (p-NENs). Data from patients who were surgically treated and pathologically diagnosed with p-NENs at the Department of Pancreatic Oncology of the Fudan University Shanghai Cancer Center (Shanghai, China), between January 2003 and July 2015, were evaluated using univariate and multivariate analyses. A total of 162 patients with p-NENs met the criteria of the present study and were included in the analysis. Patients with poorly differentiated pancreatic neuroendocrine carcinoma (p-NEC) exhibited a significantly increased rate of lymph node metastasis, as compared with patients with grade (G)1/G2 pancreatic neuroendocrine tumors (p-NETs) (62.5 vs. 20.5%, P=0.003). Univariate analysis identified that the following factors led to decreased overall survival (OS): Lymph node metastasis (P=0.001, vs. the absence of lymph node metastasis); distant metastasis (P=0.043, vs. the absence of distant metastasis); resection margin R1/R2 (P=0.030, vs. R0 resection); NEC G3 (P<0.001, vs. NET G1). Following the multivariate analysis, NEC G3 remained a statistically significant risk factor (HR=12.593; 95% CI, 3.476-45.622; P<0.001, vs. NET G1/G2). Furthermore, according to the proliferation marker protein Ki-67 staining index, assigning a grade using the proliferative index (G1, ≤5%; G2, >5-20%; G3, >20%) was more efficient for prognostic stratification compared with the European Neuroendocrine Tumor Society (Berlin, Germany)/World Health Organization (Geneva, Switzerland) 2010 grading classification. The present study indicated that p-NEC was an important predictor of decreased OS in Chinese patients. Furthermore, a Ki-67 staining index of 5% represented a more efficient value for the distinction between G1 and G2. [ABSTRACT FROM AUTHOR]
Copyright of Oncology Letters is the property of Spandidos Publications UK Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Academic Search Complete
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
CustomLinks:
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:a9h&genre=article&issn=17921074&ISBN=&volume=13&issue=5&date=20170501&spage=3163&pages=3163-3168&title=Oncology Letters&atitle=Clinical%20outcomes%20and%20prognostic%20factors%20of%20resected%20pancreatic%20neuroendocrine%20neoplasms%3A%20A%20single-center%20experience%20in%20China.&aulast=KAIZHOU%20JIN&id=DOI:10.3892/ol.2017.5834
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
Header DbId: a9h
DbLabel: Academic Search Complete
An: 122571155
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Clinical outcomes and prognostic factors of resected pancreatic neuroendocrine neoplasms: A single-center experience in China.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22KAIZHOU+JIN%22&quot;&gt;KAIZHOU JIN&lt;/searchLink&gt;&lt;relatesTo&gt;1,2,3&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22GUOPEI+LUO%22&quot;&gt;GUOPEI LUO&lt;/searchLink&gt;&lt;relatesTo&gt;1,2,3&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22JIN+XU%22&quot;&gt;JIN XU&lt;/searchLink&gt;&lt;relatesTo&gt;1,2,3&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22BO+ZHANG%22&quot;&gt;BO ZHANG&lt;/searchLink&gt;&lt;relatesTo&gt;1,2,3&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22CHEN+LIU%22&quot;&gt;CHEN LIU&lt;/searchLink&gt;&lt;relatesTo&gt;1,2,3&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22SHUNRONG+JI%22&quot;&gt;SHUNRONG JI&lt;/searchLink&gt;&lt;relatesTo&gt;1,2,3&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22LIANG+LIU%22&quot;&gt;LIANG LIU&lt;/searchLink&gt;&lt;relatesTo&gt;1,2,3&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22JIANG+LONG%22&quot;&gt;JIANG LONG&lt;/searchLink&gt;&lt;relatesTo&gt;1,2,3&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22QUANXING+NI%22&quot;&gt;QUANXING NI&lt;/searchLink&gt;&lt;relatesTo&gt;1,2,3&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22XIANJUN+YU%22&quot;&gt;XIANJUN YU&lt;/searchLink&gt;&lt;relatesTo&gt;1,2,3&lt;/relatesTo&gt;&lt;i&gt; yuxianjun@fudanpci.org&lt;/i&gt;
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Oncology+Letters%22&quot;&gt;Oncology Letters&lt;/searchLink&gt;. May2017, Vol. 13 Issue 5, p3163-3168. 6p.
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: *&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22NEUROENDOCRINE+tumors%22&quot;&gt;NEUROENDOCRINE tumors&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22PANCREATIC+diseases%22&quot;&gt;PANCREATIC diseases&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22PROGNOSIS%22&quot;&gt;PROGNOSIS&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22TUMOR+grading%22&quot;&gt;TUMOR grading&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22MULTIVARIATE+analysis%22&quot;&gt;MULTIVARIATE analysis&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The aim of the present study was to investigate the clinical, pathological and prognostic characteristics of Chinese patients with resected pancreatic neuroendocrine neoplasms (p-NENs). Data from patients who were surgically treated and pathologically diagnosed with p-NENs at the Department of Pancreatic Oncology of the Fudan University Shanghai Cancer Center (Shanghai, China), between January 2003 and July 2015, were evaluated using univariate and multivariate analyses. A total of 162 patients with p-NENs met the criteria of the present study and were included in the analysis. Patients with poorly differentiated pancreatic neuroendocrine carcinoma (p-NEC) exhibited a significantly increased rate of lymph node metastasis, as compared with patients with grade (G)1/G2 pancreatic neuroendocrine tumors (p-NETs) (62.5 vs. 20.5%, P=0.003). Univariate analysis identified that the following factors led to decreased overall survival (OS): Lymph node metastasis (P=0.001, vs. the absence of lymph node metastasis); distant metastasis (P=0.043, vs. the absence of distant metastasis); resection margin R1/R2 (P=0.030, vs. R0 resection); NEC G3 (P&lt;0.001, vs. NET G1). Following the multivariate analysis, NEC G3 remained a statistically significant risk factor (HR=12.593; 95% CI, 3.476-45.622; P&lt;0.001, vs. NET G1/G2). Furthermore, according to the proliferation marker protein Ki-67 staining index, assigning a grade using the proliferative index (G1, ≤5%; G2, &gt;5-20%; G3, &gt;20%) was more efficient for prognostic stratification compared with the European Neuroendocrine Tumor Society (Berlin, Germany)/World Health Organization (Geneva, Switzerland) 2010 grading classification. The present study indicated that p-NEC was an important predictor of decreased OS in Chinese patients. Furthermore, a Ki-67 staining index of 5% represented a more efficient value for the distinction between G1 and G2. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of Oncology Letters is the property of Spandidos Publications UK Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder&#39;s express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=a9h&AN=122571155
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.3892/ol.2017.5834
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 6
        StartPage: 3163
    Subjects:
      – SubjectFull: NEUROENDOCRINE tumors
        Type: general
      – SubjectFull: PANCREATIC diseases
        Type: general
      – SubjectFull: PROGNOSIS
        Type: general
      – SubjectFull: TUMOR grading
        Type: general
      – SubjectFull: MULTIVARIATE analysis
        Type: general
    Titles:
      – TitleFull: Clinical outcomes and prognostic factors of resected pancreatic neuroendocrine neoplasms: A single-center experience in China.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: KAIZHOU JIN
      – PersonEntity:
          Name:
            NameFull: GUOPEI LUO
      – PersonEntity:
          Name:
            NameFull: JIN XU
      – PersonEntity:
          Name:
            NameFull: BO ZHANG
      – PersonEntity:
          Name:
            NameFull: CHEN LIU
      – PersonEntity:
          Name:
            NameFull: SHUNRONG JI
      – PersonEntity:
          Name:
            NameFull: LIANG LIU
      – PersonEntity:
          Name:
            NameFull: JIANG LONG
      – PersonEntity:
          Name:
            NameFull: QUANXING NI
      – PersonEntity:
          Name:
            NameFull: XIANJUN YU
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Text: May2017
              Type: published
              Y: 2017
          Identifiers:
            – Type: issn-print
              Value: 17921074
          Numbering:
            – Type: volume
              Value: 13
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: Oncology Letters
              Type: main
ResultId 1