Bibliographic Details
| Title: |
Clinical outcomes and prognostic factors of resected pancreatic neuroendocrine neoplasms: A single-center experience in China. |
| Authors: |
KAIZHOU JIN1,2,3, GUOPEI LUO1,2,3, JIN XU1,2,3, BO ZHANG1,2,3, CHEN LIU1,2,3, SHUNRONG JI1,2,3, LIANG LIU1,2,3, JIANG LONG1,2,3, QUANXING NI1,2,3, XIANJUN YU1,2,3 yuxianjun@fudanpci.org |
| Source: |
Oncology Letters. May2017, Vol. 13 Issue 5, p3163-3168. 6p. |
| Subject Terms: |
*NEUROENDOCRINE tumors, *PANCREATIC diseases, *PROGNOSIS, *TUMOR grading, *MULTIVARIATE analysis |
| Abstract: |
The aim of the present study was to investigate the clinical, pathological and prognostic characteristics of Chinese patients with resected pancreatic neuroendocrine neoplasms (p-NENs). Data from patients who were surgically treated and pathologically diagnosed with p-NENs at the Department of Pancreatic Oncology of the Fudan University Shanghai Cancer Center (Shanghai, China), between January 2003 and July 2015, were evaluated using univariate and multivariate analyses. A total of 162 patients with p-NENs met the criteria of the present study and were included in the analysis. Patients with poorly differentiated pancreatic neuroendocrine carcinoma (p-NEC) exhibited a significantly increased rate of lymph node metastasis, as compared with patients with grade (G)1/G2 pancreatic neuroendocrine tumors (p-NETs) (62.5 vs. 20.5%, P=0.003). Univariate analysis identified that the following factors led to decreased overall survival (OS): Lymph node metastasis (P=0.001, vs. the absence of lymph node metastasis); distant metastasis (P=0.043, vs. the absence of distant metastasis); resection margin R1/R2 (P=0.030, vs. R0 resection); NEC G3 (P<0.001, vs. NET G1). Following the multivariate analysis, NEC G3 remained a statistically significant risk factor (HR=12.593; 95% CI, 3.476-45.622; P<0.001, vs. NET G1/G2). Furthermore, according to the proliferation marker protein Ki-67 staining index, assigning a grade using the proliferative index (G1, ≤5%; G2, >5-20%; G3, >20%) was more efficient for prognostic stratification compared with the European Neuroendocrine Tumor Society (Berlin, Germany)/World Health Organization (Geneva, Switzerland) 2010 grading classification. The present study indicated that p-NEC was an important predictor of decreased OS in Chinese patients. Furthermore, a Ki-67 staining index of 5% represented a more efficient value for the distinction between G1 and G2. [ABSTRACT FROM AUTHOR] |
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| Database: |
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