Bibliographic Details
| Title: |
Oseltamivir resistance in an influenza A (H3N2) virus isolated from an immunocompromised patient during the 2014-2015 influenza season in Alberta, Canada. |
| Authors: |
Chaudhry, Ahsan1, Bastien, Nathalie2, Li, Yan2, Scott, Allison3, Pabbaraju, Kanti4, Stewart, Douglas1, Wong, Sallene4, Drews, Steven J.5,6 Steven.Drews@albertahealthservices.ca |
| Source: |
Influenza & Other Respiratory Viruses. Nov2016, Vol. 10 Issue 6, p532-535. 4p. |
| Subject Terms: |
*OSELTAMIVIR, *INFLUENZA A virus, *IMMUNOCOMPROMISED patients, *NEURAMINIDASE, *GENETIC mutation, *RELENZA (Drug) |
| Abstract: |
This manuscript describes the identification of an oseltamivir-resistant influenza A (H3N2) virus in a respiratory specimen collected from an immunocompromised patient in Alberta, Canada, during the 2014-2015 influenza season. Following treatment with oseltamivir, neuraminidase ( NA) gene sequencing indicated the presence of an R292K mutation. Phenotypic susceptibility testing by the NA-Star assay indicated a highly reduced inhibition by oseltamivir and normal inhibition by zanamivir. The use of zanamivir following identification of the oseltamivir-resistant strain, combined with a partial immune reconstitution, was followed by a suggested decrease in the nasopharyngeal viral load in the nasopharynx and clinical improvement of the patient. [ABSTRACT FROM AUTHOR] |
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