Bibliographic Details
| Title: |
Neuraminidase Inhibitors from the Fruiting Body of Phellinus igniarius. |
| Authors: |
Ji-Yul Kim1, Dae-Won Kim1, Byung Soon Hwang1, E-Eum Woo1, Yoon-Ju Lee1, Kyeong-Woon Jeong1, In-Kyoung Lee1, Bong-Sik Yun1 bsyun@jbnu.ac.kr |
| Source: |
Mycobiology. Jun2016, Vol. 44 Issue 2, p117-120. 4p. |
| Subject Terms: |
*NEURAMINIDASE, *COLUMN chromatography, *ELECTROSPRAY ionization mass spectrometry, *NUCLEAR magnetic resonance, THERAPEUTIC use of fungi |
| Abstract: |
During our ongoing investigation of neuraminidase inhibitors from medicinal fungi, we found that the fruiting bodies of Phellinus igniarius exhibited significant inhibitory activity against neuraminidase from recombinant H3N2 influenza viruses. Two active compounds were isolated from the methanolic extract of P. igniarius through solvent partitioning and Sephadex LH-20 column chromatography. The active compounds were identified as phelligridins E and G on proton nuclear magnetic resonance (1H NMR) and electrospray ionization mass measurements. These compounds inhibited neuraminidases from recombinant rvH1N1, H3N2, and H5N1 influenza viruses, with IC50 values in the range of 0.7~8.1 μM. [ABSTRACT FROM AUTHOR] |
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| Database: |
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