Bibliographic Details
| Title: |
Use of the Electronic Medical Record to Assess Pancreas Size in Type 1 Diabetes. |
| Authors: |
Virostko, John1,2 jack.virostko@Vanderbilt.edu, Hilmes, Melissa2,3, Eitel, Kelsey4, Moore, Daniel J.3,5, Powers, Alvin C.6,7,8 |
| Source: |
PLoS ONE. 7/8/2016, Vol. 11 Issue 7, p1-13. 13p. |
| Subject Terms: |
*TYPE 1 diabetes, *TREATMENT of diabetes, *ELECTRONIC health records, *PANCREAS, *DIAGNOSIS, *PATIENTS, *ANATOMY |
| Abstract: |
Aims: This study harnessed the electronic medical record to assess pancreas volume in patients with type 1 diabetes (T1D) and matched controls to determine whether pancreas volume is altered in T1D and identify covariates that influence pancreas volume. Methods: This study included 25 patients with T1D and 25 age-, sex-, and weight-matched controls from the Vanderbilt University Medical Center enterprise data warehouse. Measurements of pancreas volume were made from medical imaging studies using magnetic resonance imaging (MRI) or computed tomography (CT). Results: Patients with T1D had a pancreas volume 47% smaller than matched controls (41.16 ml vs. 77.77 ml, P < 0.0001) as well as pancreas volume normalized by subject body weight, body mass index, or body surface area (all P < 0.0001). Pancreatic volume was smaller with a longer duration of T1D across the patient population (N = 25, P = 0.04). Additionally, four individual patients receiving multiple imaging scans displayed progressive declines in pancreas volume over time (~ 6% of volume/year), whereas five controls scanned a year apart did not exhibit a decline in pancreas size (P = 0.03). The pancreas was uniformly smaller on the right and left side of the abdomen. Conclusions: Pancreas volume declines with disease duration in patients with T1D, suggesting a protracted pathological process that may include the exocrine pancreas. [ABSTRACT FROM AUTHOR] |
|
Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Complete |
