| Title: |
Immunological effects in patients with steroid-refractory graft-versus-host disease following treatment with basiliximab, a CD25 monoclonal antibody. |
| Authors: |
Chakupurakal, Geothy1, García‐Márquez, María Alejandra1, Shimabukuro‐Vornhagen, Alexander1, Theurich, Sebastian2, Holtick, Udo1, Hallek, Michael1, Scheid, Christof1, Bergwelt‐Baildon, Michael1 |
| Source: |
European Journal of Haematology. Aug2016, Vol. 97 Issue 2, p121-127. 7p. |
| Subject Terms: |
*GRAFT versus host disease, *STEM cell transplantation, *THERAPEUTIC use of monoclonal antibodies, *T cells, *B cells, *KILLER cells, *DENDRITIC cells |
| Abstract: |
Steroid-refractory graft-versus-host disease (Gv HD) is a complication following an allogeneic stem cell transplantation with limited therapeutic options. Studies have shown a response in up to 80% of patients with this condition after treatment with the CD25 monoclonal antibody, basiliximab. Despite the good responses to treatment, around 50% of the patients experience recurrence of their Gv HD symptoms 4-6 wk following cessation of therapy. The in vivo changes in the following treatment with this antibody have not been elucidated so far. We treated 14 patients with severe steroid-refractory Gv HD with basiliximab weekly for 4 wk and monitored the changes in the T-, B-, NK- and dendritic cell subsets over this time period. The overall response to treatment was 92% (13/14) with 50% (7/14) achieving a complete response. Fifty four percentage (7/13) of the patients who responded showed recurrence of their Gv HD symptoms. Contrary to expectations, our observations showed a significant depletion of the regulatory T-cell subset following treatment. Our findings suggest that the undesirable depletion of the regulatory T cells along with the CD25+ acute inflammatory cells might be responsible for the high incidence of Gv HD recurrence in this cohort of patients. [ABSTRACT FROM AUTHOR] |
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