Bibliographic Details
| Title: |
Impact of β-glucan on the Fecal Water Genotoxicity of Polypectomized Patients. |
| Authors: |
Turunen, Katja T.1 (AUTHOR), Pletsa, Vasiliki2 (AUTHOR), Georgiadis, Panagiotis2 (AUTHOR), Triantafillidis, John K.3 (AUTHOR), Karamanolis, Dimitrios4 (AUTHOR), Kyriacou, Adamantini1 (AUTHOR) mkyriacou@hua.gr |
| Source: |
Nutrition & Cancer. 2016, Vol. 68 Issue 4, p560-567. 8p. 1 Chart, 1 Graph. |
| Subject Terms: |
*FECES, *ANALYSIS of variance, *ARTIFICIAL feeding, *CELL culture, *GLUCOSE, *COLON tumors, *MEDICAL care, *NUTRITION, *PATIENTS, *POLYSACCHARIDES, *QUESTIONNAIRES, *SMOKING, *DATA analysis, *BODY mass index, *PHYSICAL activity, *DIARY (Literary form), *COLON polyps, *SYMPTOMS, *PHYSIOLOGY, *DIAGNOSIS, *CANCER risk factors, RECTUM tumors |
| Abstract: |
The aim of the study was to determine the effect of β-glucan on the cytotoxicity and genotoxicity of polypectomized patient's fecal water (FW). Polypectomized volunteers (n = 69) were randomly assigned to consume bread with or without β-glucan, for 3 months. FW was collected at the beginning (t = 0), the 30th and 90th day and 2 wk after the intervention. Cytotoxicity and genotoxicity were estimated on Caco-2 cells, using trypan blue exclusion test and comet assay, respectively. Gastrointestinal symptoms were recorded and subjects kept a 3-day food diary at baseline and after completion. Trypan blue exclusion test revealed cell survival of approximately 87% after incubation with FW. The FW samples showed 49% genotoxicity at the baseline. Genotoxicity in the intervention group decreased during the trial reaching statistical significance on the 90th day compared to control. An increase was noticed 2 wk after the trial, but it still remained significantly lower compared to control. Group-specific analysis for β-glucan also revealed significant decrease in the genotoxicity on the 90th day compared to baseline. β-glucan ingestion in polypectomized patients significantly decreased the genotoxicity of their FW. Our findings suggest that β-glucan consumption could possibly provide protection against colon cancer development. [ABSTRACT FROM AUTHOR] |
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