Bibliographic Details
| Title: |
Drug Delivery Systems Obtained from Silica Based Organic-Inorganic Hybrids. |
| Authors: |
Oshiro Junior, João Augusto1 joaooshiro@yahoo.com.br, Abuçafy, Marina Paiva1 marina.abucafy@gmail.com, Manaia, Eloísa Berbel1 elobm_elo@yahoo.com.br, da Silva, Bruna Lallo1 brunalallo@hotmail.com, Chiari-Andréo, Bruna Galdorfini1,2 brunagchiari@yahoo.com.br, Chiavacci, Leila Aparecida1 leila@fcfar.unesp.br |
| Source: |
Polymers (20734360). 2016, Vol. 8 Issue 4, p91. 14p. |
| Subject Terms: |
*DRUG delivery systems, *SILICA, *INORGANIC chemistry, *ORGANIC chemistry |
| Abstract: |
This is a review of hybrid materials based on silica as an inorganic phase used as drug delivery systems (DDS). Silica based DDS have shown effectivity when compared with traditional delivery systems. They present advantages such as: (a) ability to maintain the therapeutic range with minor variations; (b) prevention of local and systemic toxic effects; (c) plasma concentrations increase of substances with a short half-life; and (d) reduction of the number of daily doses, which may increase patient adherence to the treatment. These advantages occur due to the physical, chemical and optical properties of these materials. Therefore, we discuss the properties and characteristics of them and we present some applications, using different approaches of DDS to ensure therapeutic effectiveness and side effects reduction such as implantable biomaterial, film-forming materials, stimuli-responsive systems and others. [ABSTRACT FROM AUTHOR] |
|
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| Database: |
Academic Search Complete |
