Bibliographic Details
| Title: |
Clinical Phenotype of Endothelial Dysfunction in Romanian Scleroderma Patients. |
| Authors: |
GROSEANU, Laura1,2 laura_groseanu@yahoo.com, BERGHEA, Florian1,2, BALANESCU, Andra1,2, PREDETEANU, Denisa1,2, BOJINCA, Violeta1,2, SAULESCU, Ioana1,2, CONSTANTINESCU, Cosmin1,2, OPRIS, Daniela1,2, ABOBULUI, Mihai1,2, BORANGIU, Andreea1,2, NEGRU, Maria-Magdalena1,2, VLAD, Violeta1,2, IONESCU, Ruxandra1,2 |
| Source: |
Maedica - a Journal of Clinical Medicine. 2016, Vol. 11 Issue 1, p26-31. 6p. |
| Subject Terms: |
*DYSPLASTIC nevus syndrome, *IMMUNOHISTOCHEMISTRY, *STAINS & staining (Microscopy), *DYSPLASIA, *MELANOMA |
| Abstract: |
Objective: to identify the particularities of the clinical phenotype of endothelial dysfunction in a lot of Romanian patients from a reference center and compare it to data reported by international registries. Material and methods: 51 patients were included in a cross-sectional study. The patients were evaluated for the pattern of disease, main visceral involvement, serum markers of disease. Results: 41.2% patients had history of digital ulcers, 27.45% had pulmonary arterial hypertension; cardiovascular involvement also included: diastolic dysfunction in 31.1% of the patients, global systolic dysfunction in 9.8%, rhythm and conduction disturbances in 19.6%, peripheral vascular disease in 19.6%. Scleroderma renal crisis was identified in 2 patients. Conclusions: Vascular complications are a major cause of morbidity and mortality in systemic sclerosis. Earlier therapeutic intervention demands improved screening and diagnosis in all cases. [ABSTRACT FROM AUTHOR] |
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| Database: |
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