Bibliographic Details
| Title: |
Synthesis of 2,4,5-Trisubstituted Furans via a Triple C(sp³)-H Functionalization Reaction Using Rongalite as the C1 Unit. |
| Authors: |
Miao Wang1, Jia-Chen Xiang1, Yan Cheng1, Yan-Dong Wu1 chwuax@mail.ccnu.edu.cn, An-Xin Wu1 chwuyd@mail.ccnu.edu.cn |
| Source: |
Organic Letters. Feb2016, Vol. 18 Issue 3, p524-527. 4p. |
| Subject Terms: |
*SUBSTITUTION reactions, *FURANS synthesis, *CARBON-hydrogen bonds, *CHEMICAL reactions, *RONGALITE, *COPPER compounds |
| Abstract: |
A highly efficient I2/Cu(NO3)2·3H2O-mediated triple C(sp³)-H functionalization reaction for the synthesis of 2,4,5-trisubstituted furans from aryl methyl ketones and rongalite by employing rongalite as a C1 unit has been developed. This method allows rapid access to (2-acyl-4-methylthio-5-aryl) furans. Preliminary mechanistic studies indicate that in situ generated dimethyl(phenacyl)-sulfonium iodine and HCHO were probably the key intermediates in this transformation. [ABSTRACT FROM AUTHOR] |
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| Database: |
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