Molecular Iodine-Mediated Chemoselective Synthesis of Multisubstituted Pyridines through Catabolism and Reconstruction Behavior of Natural Amino Acids.

Bibliographic Details
Title:	Molecular Iodine-Mediated Chemoselective Synthesis of Multisubstituted Pyridines through Catabolism and Reconstruction Behavior of Natural Amino Acids.
Authors:	Jia-Chen Xiang¹, Miao Wang¹, Yan Cheng¹, An-Xin Wu¹ chwuax@mail.ccnu.edu.cn
Source:	Organic Letters. Jan2016, Vol. 18 Issue 1, p24-27. 4p.
Subject Terms:	AMINO acids, DECARBOXYLATION, PYRIDINE, IODINE compounds, *SUBSTITUTION reactions
Abstract:	A new process has been developed for the selective construction of 2,6-disubstituted, 2,4,6-trisubstituted, and 3,5-disubstituted pyridines based on the catabolism and reconstruction behaviors of amino acids. Molecular iodine was used as a tandem catalyst to trigger the decarboxylation-deamination of amino acids and to promote the subsequent formation of the pyridine products. [ABSTRACT FROM AUTHOR]
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