Bibliographic Details
| Title: |
Effect of context exposure after fear learning on memory generalization in mice. |
| Authors: |
Ayano Fujinaka1, Ruoshi Li1, Masanobu Hayashi1, Kumar, Deependra1, Changarathil, Gopakumar1, Keisuke Naito1, Kousuke Miki1, Taihei Nishiyama1, Lazarus, Michael1, Takeshi Sakurai1,2, Nohjin Kee3, Satomi Nakajima4, Szu-Han Wang5, Masanori Sakaguchi1 masanori.sakaguchi@gmail.com |
| Source: |
Molecular Brain. 1/8/2016, Vol. 9, p1-7. 7p. |
| Subject Terms: |
*MEMORY research, *LEARNING, *FEAR, *LABORATORY mice, *STIMULUS generalization, *CONDITIONED response |
| Abstract: |
Background: The conditions under which memory generalization occurs are not well understood. Although it is believed that fear memory generalization is gradually established after learning, it is not clear whether experiences soon after learning affect generalization. Results: Using a contextual fear conditioning paradigm in mice, we found that fear memory generalization occurred when mice were exposed to a familiar, unconditioned context soon after fear learning. Conclusions: Our results suggest that the familiarity of contexts and the timing of their exposure influences memory generalization, which increases our understanding of the mechanisms of generalization. [ABSTRACT FROM AUTHOR] |
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| Database: |
Academic Search Complete |
