Bibliographic Details
| Title: |
Stimuli-Triggered Activity of Nanoreactors by BiomimeticEngineering Polymer Membranes. |
| Authors: |
Tomaž Einfalt1, Roland Goers1, IonelAdrian Dinu1, Adrian Najer1, Mariana Spulber1, Ozana Onaca-Fischer1, Cornelia G. Palivan1 |
| Source: |
Nano Letters. Nov2015, Vol. 15 Issue 11, p7596-7603. 8p. |
| Subject Terms: |
*CHEMICAL reactors, *NANOSTRUCTURED materials, *POLYMERIC membranes, *BIOMIMETIC chemicals, *PH effect, *MICROENCAPSULATION |
| Abstract: |
The development of advanced stimuli-responsivesystems for medicine, catalysis, or technology requires compartmentalizedreaction spaces with triggered activity. Only very few stimuli-responsivesystems preserve the compartment architecture, and none allows a triggeredactivity in situ. We present here a biomimetic strategy to moleculartransmembrane transport by engineering synthetic membranes equippedwith channel proteins so that they are stimuli-responsive. Nanoreactorswith triggered activity were designed by simultaneously encapsulatingan enzyme inside polymer compartments, and inserting protein “gates”in the membrane. The outer membrane protein F (OmpF) porin was chemicallymodified with a pH-responsive molecular cap to serve as “gate”producing pH-driven molecular flow through the membrane and controlthe in situ enzymatic activity. This strategy provides complex reactionspaces necessary in “smart” medicine and for biomimeticengineering of artificial cells. [ABSTRACT FROM AUTHOR] |
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| Database: |
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