Bibliographic Details
| Title: |
A Reminder of Methylene Blue's Effectiveness. |
| Authors: |
Manghelli, Joshua1,2 jmanghelli@atsu.edu, Brown, Lisa3, Tadros, Hany B.4, Munfakh, Nabil A.3 |
| Source: |
Texas Heart Institute Journal. Oct2015, Vol. 42 Issue 5, p491-494. 4p. 1 Diagram, 1 Graph. |
| Subject Terms: |
*DRUG therapy, *METHYLENE blue, *CARDIAC surgery, *CARDIOPULMONARY bypass, *HEMODYNAMICS, *THERAPEUTICS |
| Abstract: |
The inflammatory response induced by cardiopulmonary bypass decreases vascular tone, which in turn can lead to vasoplegic syndrome. Indeed the hypotension consequent to on-pump cardiac surgery often necessitates vasopressor and intravenous fluid support. Methylene blue counteracts vasoplegic syndrome by inhibiting the formation of nitric oxide. We report the use of methylene blue in a 75-year-old man who developed vasoplegic syndrome after cardiac surgery. After the administration of methylene blue, his hypotension improved to the extent that he could be weaned from vasopressors. The use of methylene blue should be considered in patients who develop hypotension refractory to standard treatment after cardiac surgery. [ABSTRACT FROM AUTHOR] |
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| Database: |
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