Bibliographic Details
| Title: |
FENO AND ATOPY IN PEDIATRIC ASTHMA. |
| Alternate Title: |
FENO ŞI ATOPIA ÎN ASTMUL BRONŞIC LA COPII. |
| Authors: |
Stanciulescu, Cristiana1 cristianastanciulescu@yahoo.com, Chiru, Mirela1,2, Oprea, Alina1, Pacurar, Daniela1,2, Zapucioiu, Carmen1,2, Petrisor, Elena1, Oraseanu, Dumitru1,2 |
| Source: |
Romanian Journal of Pediatrics / Revista Romana de Pediatrie. 2015, Vol. 64 Issue 2, p136-202. 8p. |
| Abstract (English): |
Objectives. The aim of this study was to determine the manner in which the level of exhaled nitric oxide (FENO) infl uences the atopic status in children with asthma. Methods. The study included 92 asthmatic children (aged 5-18 years) admitted on the Pediatric Clinic of “Grigore Alexandrescu” Emergency Clinical Hospital for Children. The atopic status was evaluated through anamnesis, clinical examination and laboratory determination of serum eosinophils and total Ig E. All children underwent measurement of FENO. Results. Children with atopic asthma had higher levels of FENO than children with nonatopic asthma. The FENO values correlate with eosinophilia and high values of immunoglobulin E. Conclusion. FENO is a useful marker for the evaluation of airway inflammation in children with atopic asthma. [ABSTRACT FROM AUTHOR] |
| Abstract (Romanian): |
Obiective. Stabilirea relaţiei între valoarea concentraţiei oxidului nitric expirat (FENO) şi atopia în astmul bronşic la copii. Metode. Au fost examinaţi 92 de pacienţi cu diagnosticul de astm bronşic stabilit, cu vârste cuprinse între 5 şi 18 ani, care s-au prezentat în Clinica de Pediatrie a Spitalului Clinic de Urgenţe pentru Copii „Grigore Alexandrescu“. Terenul atopic a fost evaluat prin date anamnestice, clinice şi investigaţii de laborator (eozinofi le serice şi IgE totale). Tuturor pacienţilor li s-a determinat concentraţia oxidului nitric expirat. Rezultate. S-au obţinut valori crescute ale FENO la copiii cu astm bronşic alergic faţă de cei cu astm bronşic nonalergic, valori care se corelează cu eozinofi lia şi creşterea imunoglobulinelor E totale. Concluzii. Măsurarea FENO este utilă pentru evaluarea infl amaţiei mucoasei bronşice la copiii cu astm bronşic atopic. [ABSTRACT FROM AUTHOR] |
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