Renal and Neurological Response with Eculizumab in a Patient with Transplant Associated Thrombotic Microangiopathy after Allogeneic Hematopoietic Progenitor Cell Transplantation.
| Title: | Renal and Neurological Response with Eculizumab in a Patient with Transplant Associated Thrombotic Microangiopathy after Allogeneic Hematopoietic Progenitor Cell Transplantation. |
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| Authors: | Sevindik, Ömür Gökmen1 omurgok17@hotmail.com, Alacacıoğlu, İnci1 inci.alacacioglu@deu.edu.tr, Katgı, Abdullah1 drakatgi@gmail.com, Solmaz, Şerife Medeni1 serife.medeni@deu.edu.tr, Acar, Celal1 celalacar@gmail.com, Pişkin, Özden1 ozden.piskin@deu.edu.tr, Özcan, Mehmet Ali1 mehmet.ozcan@deu.edu.tr, Demirkan, Fatih1 fatih.demirkan@deu.edu.tr, Ündar, Bülent1 bulent.undar@deu.edu.tr, Özsan, Güner Hayri1 hayri.ozsan@deu.edu.tr |
| Source: | Case Reports in Hematology. 1/29/2015, Vol. 2015, p1-4. 4p. |
| Subject Terms: | *THROMBOTIC thrombocytopenic purpura treatment, *NEUROLOGY, *ECULIZUMAB, *PROGENITOR cells, *HEMATOPOIETIC stem cell transplantation, *STIMULUS & response (Biology), *THERAPEUTICS |
| Abstract: | Transplantation-associated thrombotic microangiopathy (TA-TMA) is a challenge after allogeneic hematopoietic progenitor cell transplantation, considering the diagnostic uncertainties and lack of established treatment. We report a 43-year-old male patient who was diagnosed as TA-TMA after allogeneic progenitor cell transplantation for a progressive ALK negative anaplastic large cell lymphoma and responded to eculizumab with dramatically improving neurological status and renal function. Rapid neurological and renal recovery achieved after eculizumab could support a possible relationship between complement activation and TA-TMA. Eculizumab should be a reasonable treatment approach in patients with TA-TMA after allogeneic hematopoietic progenitor cell transplantation. [ABSTRACT FROM AUTHOR] |
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| Items | – Name: Title Label: Title Group: Ti Data: Renal and Neurological Response with Eculizumab in a Patient with Transplant Associated Thrombotic Microangiopathy after Allogeneic Hematopoietic Progenitor Cell Transplantation. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Sevindik%2C+Ömür+Gökmen%22">Sevindik, Ömür Gökmen</searchLink><relatesTo>1</relatesTo><i> omurgok17@hotmail.com</i><br /><searchLink fieldCode="AR" term="%22Alacacıoğlu%2C+İnci%22">Alacacıoğlu, İnci</searchLink><relatesTo>1</relatesTo><i> inci.alacacioglu@deu.edu.tr</i><br /><searchLink fieldCode="AR" term="%22Katgı%2C+Abdullah%22">Katgı, Abdullah</searchLink><relatesTo>1</relatesTo><i> drakatgi@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Solmaz%2C+Şerife+Medeni%22">Solmaz, Şerife Medeni</searchLink><relatesTo>1</relatesTo><i> serife.medeni@deu.edu.tr</i><br /><searchLink fieldCode="AR" term="%22Acar%2C+Celal%22">Acar, Celal</searchLink><relatesTo>1</relatesTo><i> celalacar@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Pişkin%2C+Özden%22">Pişkin, Özden</searchLink><relatesTo>1</relatesTo><i> ozden.piskin@deu.edu.tr</i><br /><searchLink fieldCode="AR" term="%22Özcan%2C+Mehmet+Ali%22">Özcan, Mehmet Ali</searchLink><relatesTo>1</relatesTo><i> mehmet.ozcan@deu.edu.tr</i><br /><searchLink fieldCode="AR" term="%22Demirkan%2C+Fatih%22">Demirkan, Fatih</searchLink><relatesTo>1</relatesTo><i> fatih.demirkan@deu.edu.tr</i><br /><searchLink fieldCode="AR" term="%22Ündar%2C+Bülent%22">Ündar, Bülent</searchLink><relatesTo>1</relatesTo><i> bulent.undar@deu.edu.tr</i><br /><searchLink fieldCode="AR" term="%22Özsan%2C+Güner+Hayri%22">Özsan, Güner Hayri</searchLink><relatesTo>1</relatesTo><i> hayri.ozsan@deu.edu.tr</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Case+Reports+in+Hematology%22">Case Reports in Hematology</searchLink>. 1/29/2015, Vol. 2015, p1-4. 4p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22THROMBOTIC+thrombocytopenic+purpura+treatment%22">THROMBOTIC thrombocytopenic purpura treatment</searchLink><br />*<searchLink fieldCode="DE" term="%22NEUROLOGY%22">NEUROLOGY</searchLink><br />*<searchLink fieldCode="DE" term="%22ECULIZUMAB%22">ECULIZUMAB</searchLink><br />*<searchLink fieldCode="DE" term="%22PROGENITOR+cells%22">PROGENITOR cells</searchLink><br />*<searchLink fieldCode="DE" term="%22HEMATOPOIETIC+stem+cell+transplantation%22">HEMATOPOIETIC stem cell transplantation</searchLink><br />*<searchLink fieldCode="DE" term="%22STIMULUS+%26+response+%28Biology%29%22">STIMULUS & response (Biology)</searchLink><br />*<searchLink fieldCode="DE" term="%22THERAPEUTICS%22">THERAPEUTICS</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Transplantation-associated thrombotic microangiopathy (TA-TMA) is a challenge after allogeneic hematopoietic progenitor cell transplantation, considering the diagnostic uncertainties and lack of established treatment. We report a 43-year-old male patient who was diagnosed as TA-TMA after allogeneic progenitor cell transplantation for a progressive ALK negative anaplastic large cell lymphoma and responded to eculizumab with dramatically improving neurological status and renal function. Rapid neurological and renal recovery achieved after eculizumab could support a possible relationship between complement activation and TA-TMA. Eculizumab should be a reasonable treatment approach in patients with TA-TMA after allogeneic hematopoietic progenitor cell transplantation. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Case Reports in Hematology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1155/2015/425410 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 4 StartPage: 1 Subjects: – SubjectFull: THROMBOTIC thrombocytopenic purpura treatment Type: general – SubjectFull: NEUROLOGY Type: general – SubjectFull: ECULIZUMAB Type: general – SubjectFull: PROGENITOR cells Type: general – SubjectFull: HEMATOPOIETIC stem cell transplantation Type: general – SubjectFull: STIMULUS & response (Biology) Type: general – SubjectFull: THERAPEUTICS Type: general Titles: – TitleFull: Renal and Neurological Response with Eculizumab in a Patient with Transplant Associated Thrombotic Microangiopathy after Allogeneic Hematopoietic Progenitor Cell Transplantation. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Sevindik, Ömür Gökmen – PersonEntity: Name: NameFull: Alacacıoğlu, İnci – PersonEntity: Name: NameFull: Katgı, Abdullah – PersonEntity: Name: NameFull: Solmaz, Şerife Medeni – PersonEntity: Name: NameFull: Acar, Celal – PersonEntity: Name: NameFull: Pişkin, Özden – PersonEntity: Name: NameFull: Özcan, Mehmet Ali – PersonEntity: Name: NameFull: Demirkan, Fatih – PersonEntity: Name: NameFull: Ündar, Bülent – PersonEntity: Name: NameFull: Özsan, Güner Hayri IsPartOfRelationships: – BibEntity: Dates: – D: 29 M: 01 Text: 1/29/2015 Type: published Y: 2015 Identifiers: – Type: issn-print Value: 20906560 Numbering: – Type: volume Value: 2015 Titles: – TitleFull: Case Reports in Hematology Type: main |
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