Bibliographic Details
| Title: |
Renal and Neurological Response with Eculizumab in a Patient with Transplant Associated Thrombotic Microangiopathy after Allogeneic Hematopoietic Progenitor Cell Transplantation. |
| Authors: |
Sevindik, Ömür Gökmen1 omurgok17@hotmail.com, Alacacıoğlu, İnci1 inci.alacacioglu@deu.edu.tr, Katgı, Abdullah1 drakatgi@gmail.com, Solmaz, Şerife Medeni1 serife.medeni@deu.edu.tr, Acar, Celal1 celalacar@gmail.com, Pişkin, Özden1 ozden.piskin@deu.edu.tr, Özcan, Mehmet Ali1 mehmet.ozcan@deu.edu.tr, Demirkan, Fatih1 fatih.demirkan@deu.edu.tr, Ündar, Bülent1 bulent.undar@deu.edu.tr, Özsan, Güner Hayri1 hayri.ozsan@deu.edu.tr |
| Source: |
Case Reports in Hematology. 1/29/2015, Vol. 2015, p1-4. 4p. |
| Subject Terms: |
*THROMBOTIC thrombocytopenic purpura treatment, *NEUROLOGY, *ECULIZUMAB, *PROGENITOR cells, *HEMATOPOIETIC stem cell transplantation, *STIMULUS & response (Biology), *THERAPEUTICS |
| Abstract: |
Transplantation-associated thrombotic microangiopathy (TA-TMA) is a challenge after allogeneic hematopoietic progenitor cell transplantation, considering the diagnostic uncertainties and lack of established treatment. We report a 43-year-old male patient who was diagnosed as TA-TMA after allogeneic progenitor cell transplantation for a progressive ALK negative anaplastic large cell lymphoma and responded to eculizumab with dramatically improving neurological status and renal function. Rapid neurological and renal recovery achieved after eculizumab could support a possible relationship between complement activation and TA-TMA. Eculizumab should be a reasonable treatment approach in patients with TA-TMA after allogeneic hematopoietic progenitor cell transplantation. [ABSTRACT FROM AUTHOR] |
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| Database: |
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