| Title: |
Safety assessment of chronic oral exposure to iron oxide nanoparticles. |
| Authors: |
Susana Chamorro1, Lucía Gutiérrez2, María Pilar Vaquero1, Dolores Verdoy3, Gorka Salas2,4,5, Yurena Luengo2, Agustín Brenes1, Francisco José Teran4,5 francisco.teran@imdea.org |
| Source: |
Nanotechnology. 5/22/2015, Vol. 26 Issue 20, p1-1. 1p. |
| Subject Terms: |
*IRON oxide nanoparticles, *ORAL diseases, *BIOAVAILABILITY, *GENE expression, *MUCINS, *BIOTRANSFORMATION (Metabolism) |
| Abstract: |
Iron oxide nanoparticles with engineered physical and biochemical properties are finding a rapidly increasing number of biomedical applications. However, a wide variety of safety concerns, especially those related to oral exposure, still need to be addressed for iron oxide nanoparticles in order to reach clinical practice. Here, we report on the effects of chronic oral exposure to low doses of γ-Fe2O3 nanoparticles in growing chickens. Animal observation, weight, and diet intake reveal no adverse signs, symptoms, or mortality. No nanoparticle accumulation was observed in liver, spleen, and duodenum, with feces as the main excretion route. Liver iron level and duodenal villi morphology reflect the bioavailability of the iron released from the partial transformation of γ-Fe2O3 nanoparticles in the acid gastric environment. Duodenal gene expression studies related to the absorption of iron from γ-Fe2O3 nanoparticles indicate the enhancement of a ferric over ferrous pathway supporting the role of mucins. Our findings reveal that oral administration of iron oxide nanoparticles is a safe route for drug delivery at low nanoparticle doses. [ABSTRACT FROM AUTHOR] |
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| Database: |
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