Bibliographic Details
| Title: |
T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility. |
| Authors: |
Ghassibe-Sabbagh, Michella1, Haber, Marc1, Salloum, Angelique K.1, Al-Sarraj, Yasser2, Akle, Yasmine3, Hirbli, Kamal1,4, Romanos, Jihane1, Mouzaya, Francis1, Gauguier, Dominique5, Platt, Daniel E.6, El-Shanti, Hatem2,7, A. Zalloua, Pierre1,8 pierre.zalloua@lau.edu.lb |
| Source: |
Scientific Reports. 12/12/2014, p1-9. 9p. |
| Subject Terms: |
*TYPE 2 diabetes, *DISEASE susceptibility, *CYCLIN-dependent kinases, *TRANSCRIPTION factors, *SINGLE nucleotide polymorphisms, *LEBANESE |
| Abstract: |
Genome-wide association studies (GWAS) of multiple populations with distinctive genetic and lifestyle backgrounds are crucial to the understanding of Type 2 Diabetes Mellitus (T2DM) pathophysiology. We report a GWAS on the genetic basis of T2DM in a 3,286 Lebanese participants. More than 5,000,000 SNPs were directly genotyped or imputed using the 1000 Genomes Project reference panels. We identify genome-wide significant variants in two loci CDKAL1 and TCF7L2, independent of sex, age and BMI, with leading variants rs7766070 (OR = 1.39, P = 4.77 ×10-9) and rs34872471 (OR = 1.35, P = 1.01 × 10-8) respectively. The current study is the first GWAS to find genomic regions implicated in T2DM in the Lebanese population. The results support a central role of CDKAL1 and TCF7L2 in T2DM susceptibility in Southwest Asian populations and provide a plausible component for understanding molecular mechanisms involved in the disease. [ABSTRACT FROM AUTHOR] |
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| Database: |
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