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Chemical composition and in vitro antibacterial activity of essential oils from Murraya paniculata (L.) Jack (Rutaceae) ripe and unripe fruits against bacterial genera Mycobacterium and Streptococcus

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Title: Chemical composition and in vitro antibacterial activity of essential oils from Murraya paniculata (L.) Jack (Rutaceae) ripe and unripe fruits against bacterial genera Mycobacterium and Streptococcus
Authors: Silva, Flávia Fernanda Alves da, Fernandes, Cassia Cristina, Santiago, Mariana Brentini, Martins, Carlos Henrique Gomes, Vieira, Tatiana Manzini, Crotti, Antônio Eduardo Miller, Miranda, Mayker Lazaro Dantas
Source: Brazilian Journal of Pharmaceutical Sciences. January 2020 56
Publisher Information: Universidade de São Paulo, Faculdade de Ciências Farmacêuticas, 2020.
Publication Year: 2020
Subject Terms: Murraya paniculata (L.) Jack, Rutaceae, Anti-streptococcal activity, Mycobacterium kansasii, Antibacterial agent, Antimycobacterial activity
More Details: This study aims to investigate chemical composition of essential oils from Murraya paniculata (L.) Jack (Rutaceae) ripe and unripe fruits and determine their in vitro antibacterial activity. Essential oils were extracted by hydrodistillation from Murraya paniculata (L.) Jack ripe and unripe fruits collected in the Cerrado, in Rio Verde, southwestern Goiás, Brazil. They were analyzed by gas chromatography with flame ionization detector (GC-FID) and by gas chromatography-mass spectrometry (GC-MS). Sesquiterpenes, which represent the most abundant class of compounds in oils, predominated in both ripe and unripe fruits. Major constituents of essential oils extracted from ripe fruits (RF-EO) were (-caryophyllene (21.3%), (-ylangene (13.3%), germacrene-D (10.9%) and (-zingiberene (9.7%) whereas the ones of unripe fruits (UF-EO) were sesquithujene (25.0%), (-zingiberene (18.2%), germacrene-D (13.1%) and (-copaene (12.7%). In vitro antibacterial activity of essential oils was evaluated in terms of its minimum inhibitory concentration (MIC) values by the broth microdilution method in 96-well microplates. Both essential oils under investigation showed moderate anti-streptococcal activity against the following bacteria: Streptococcus mutans, S. mitis, S. sanguinis, S. sobrinus and S. salivarius. MIC values ranged between 100 and 400 µg/mL. Regarding the antimycobacterial activity, essential oils from M. paniculata (L.) Jack unripe and ripe fruits were active against Mycobacterium kansasii (MIC = 250 µg/mL), moderately active against M. tuberculosis (MIC = 500 µg/mL) and inactive against M. avium (MIC = 2000 µg/mL). This study was pioneer in revealing similar chemical profiles of both essential oils extracted from Murraya paniculata (L.) Jack unripe and ripe fruits, besides describing their in vitro anti-streptococcal and antimycobacterial activities.
Document Type: article
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Language: English
ISSN: 1984-8250
DOI: 10.1590/s2175-97902019000418371
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  Data: Chemical composition and in vitro antibacterial activity of essential oils from Murraya paniculata (L.) Jack (Rutaceae) ripe and unripe fruits against bacterial genera Mycobacterium and Streptococcus
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  Data: <searchLink fieldCode="AR" term="%22Silva%2C+Flávia+Fernanda+Alves+da%22">Silva, Flávia Fernanda Alves da</searchLink><br /><searchLink fieldCode="AR" term="%22Fernandes%2C+Cassia+Cristina%22">Fernandes, Cassia Cristina</searchLink><br /><searchLink fieldCode="AR" term="%22Santiago%2C+Mariana+Brentini%22">Santiago, Mariana Brentini</searchLink><br /><searchLink fieldCode="AR" term="%22Martins%2C+Carlos+Henrique+Gomes%22">Martins, Carlos Henrique Gomes</searchLink><br /><searchLink fieldCode="AR" term="%22Vieira%2C+Tatiana+Manzini%22">Vieira, Tatiana Manzini</searchLink><br /><searchLink fieldCode="AR" term="%22Crotti%2C+Antônio+Eduardo+Miller%22">Crotti, Antônio Eduardo Miller</searchLink><br /><searchLink fieldCode="AR" term="%22Miranda%2C+Mayker+Lazaro+Dantas%22">Miranda, Mayker Lazaro Dantas</searchLink>
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  Data: <i>Brazilian Journal of Pharmaceutical Sciences</i>. January 2020 56
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  Data: Universidade de São Paulo, Faculdade de Ciências Farmacêuticas, 2020.
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  Data: 2020
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  Data: <searchLink fieldCode="DE" term="%22Murraya+paniculata+%28L%2E%29+Jack%22">Murraya paniculata (L.) Jack</searchLink><br /><searchLink fieldCode="DE" term="%22Rutaceae%22">Rutaceae</searchLink><br /><searchLink fieldCode="DE" term="%22Anti-streptococcal+activity%22">Anti-streptococcal activity</searchLink><br /><searchLink fieldCode="DE" term="%22Mycobacterium+kansasii%22">Mycobacterium kansasii</searchLink><br /><searchLink fieldCode="DE" term="%22Antibacterial+agent%22">Antibacterial agent</searchLink><br /><searchLink fieldCode="DE" term="%22Antimycobacterial+activity%22">Antimycobacterial activity</searchLink>
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  Data: This study aims to investigate chemical composition of essential oils from Murraya paniculata (L.) Jack (Rutaceae) ripe and unripe fruits and determine their in vitro antibacterial activity. Essential oils were extracted by hydrodistillation from Murraya paniculata (L.) Jack ripe and unripe fruits collected in the Cerrado, in Rio Verde, southwestern Goiás, Brazil. They were analyzed by gas chromatography with flame ionization detector (GC-FID) and by gas chromatography-mass spectrometry (GC-MS). Sesquiterpenes, which represent the most abundant class of compounds in oils, predominated in both ripe and unripe fruits. Major constituents of essential oils extracted from ripe fruits (RF-EO) were (-caryophyllene (21.3%), (-ylangene (13.3%), germacrene-D (10.9%) and (-zingiberene (9.7%) whereas the ones of unripe fruits (UF-EO) were sesquithujene (25.0%), (-zingiberene (18.2%), germacrene-D (13.1%) and (-copaene (12.7%). In vitro antibacterial activity of essential oils was evaluated in terms of its minimum inhibitory concentration (MIC) values by the broth microdilution method in 96-well microplates. Both essential oils under investigation showed moderate anti-streptococcal activity against the following bacteria: Streptococcus mutans, S. mitis, S. sanguinis, S. sobrinus and S. salivarius. MIC values ranged between 100 and 400 µg/mL. Regarding the antimycobacterial activity, essential oils from M. paniculata (L.) Jack unripe and ripe fruits were active against Mycobacterium kansasii (MIC = 250 µg/mL), moderately active against M. tuberculosis (MIC = 500 µg/mL) and inactive against M. avium (MIC = 2000 µg/mL). This study was pioneer in revealing similar chemical profiles of both essential oils extracted from Murraya paniculata (L.) Jack unripe and ripe fruits, besides describing their in vitro anti-streptococcal and antimycobacterial activities.
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        Value: 10.1590/s2175-97902019000418371
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