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Nutritional and hematological factors associated with the progression of Alzheimer's disease: a cohort study

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Title: Nutritional and hematological factors associated with the progression of Alzheimer's disease: a cohort study
Authors: Gregório, Elizama de, Patrzyk, Luan Henrique, Fiebrantz, Anne Karine Bosetto, Bonini, Juliana Sartori, Cambruzzi, Dayanna Hartmann, Diedrich, Camila, Fermino, Bárbara Luisa, Fabbri, Roberta, Silva, Weber Cláudio Francisco Nunes da
Source: Revista da Associação Médica Brasileira. February 2019 65(2)
Publisher Information: Associação Médica Brasileira, 2019.
Publication Year: 2019
Subject Terms: Alzheimer disease, Obesity, Macronutrients, Dementia
More Details: SUMMARY OBJECTIVE: We studied the users of the Specialized Drug Distribution Program of the public health network. METHODS: A prospective cohort examined the elderly at two intervals of three years and included 30 patients in phase I and 16 in phase II. The methodology was composed of home visits, anthropometric, nutritional and hematological evaluation. For the progression of AD, the Clinical Dementia Rating (CDR) scale was used. RESULTS: According to the CDR, the disease evolved, since in 2014 most of the patients were in CDR 3. In the analysis of the micronutrients, only the B vitamins (B1, B2, B3, B5, B6) presented a significant reduction in 2014. The consumption of carbohydrates and lipids increased in the 2014 evaluation, and protein consumption decreased. As for the average weight of the elderly, there was an increase in 2014, 65.9 (± 15.6) Kg, with a BMI of 26.75 (± 4, 5), in 2011 the average weight was 62.44 kg (± 14, 36), BMI 24.64 (± 4.97). CONCLUSION: The hypothesis that patients are likely to be overweight or obese before the development of AD and that this may be associated with an increased risk of dementia is suggested.
Document Type: article
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Language: English
ISSN: 0104-4230
DOI: 10.1590/1806-9282.65.2.222
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  Data: <i>Revista da Associação Médica Brasileira</i>. February 2019 65(2)
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  Data: SUMMARY OBJECTIVE: We studied the users of the Specialized Drug Distribution Program of the public health network. METHODS: A prospective cohort examined the elderly at two intervals of three years and included 30 patients in phase I and 16 in phase II. The methodology was composed of home visits, anthropometric, nutritional and hematological evaluation. For the progression of AD, the Clinical Dementia Rating (CDR) scale was used. RESULTS: According to the CDR, the disease evolved, since in 2014 most of the patients were in CDR 3. In the analysis of the micronutrients, only the B vitamins (B1, B2, B3, B5, B6) presented a significant reduction in 2014. The consumption of carbohydrates and lipids increased in the 2014 evaluation, and protein consumption decreased. As for the average weight of the elderly, there was an increase in 2014, 65.9 (± 15.6) Kg, with a BMI of 26.75 (± 4, 5), in 2011 the average weight was 62.44 kg (± 14, 36), BMI 24.64 (± 4.97). CONCLUSION: The hypothesis that patients are likely to be overweight or obese before the development of AD and that this may be associated with an increased risk of dementia is suggested.
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