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EFFICACY OF CURCUMA LONGA IN THE TREATMENT OF DIVERSION COLITIS IN RATS

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Title: EFFICACY OF CURCUMA LONGA IN THE TREATMENT OF DIVERSION COLITIS IN RATS
Authors: LIMA, Arthur Medeiros, NASCIMENTO, Carlos Eduardo Costa, SANTOS, Carlos Henrique Marques dos, DOURADO, Doroty Mesquita, SIQUEIRA, Gabriel Elias Cardoso, RIGO, Giovana Maria, BERNARDI, Lauren Umpierre, LEONEL, Paulo Otávio Souza, MATIAS, Rosemary, FERREIRA, Vitor Caldas, SOUZA, Vitor Cruz Rosa Pires de
Source: ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo). January 2019 32(3)
Publisher Information: Colégio Brasileiro de Cirurgia Digestiva, 2019.
Publication Year: 2019
Subject Terms: Curcuma, zingibereceae, Colite, Anti-inflamatórios, Ratos, Colostomia
More Details: Background: Diversion colitis is still very common in our country, since the stoma creation is a common practice especially in situations of trauma. needing treatment for this condition. Aim: To evaluate the therapeutic effect of rectal infusion of Curcuma longa (turmeric) in the excluded intestinal segment of rats. Method: Eighteen Wistar rats were used and submitted to colostomy: control group (n=8) under rectal saline infusion and group CL, receiving intra-rectal infusion of Curcuma longa extract (n=10). After 21 days of treatment they were submitted to euthanasia; the intestinal segment excluded from intestinal transit was resected and sent to histopathological evaluation, classifying the degree of inflammation and of vascular congestion. Results: The average of inflammation was 2.7 in the control group vs. 2.6 in the CL group (p=0.3125), while the mean vascular congestion was 2.3 and 2.1, respectively, in the control and CL groups (p=0.1642). Conclusion: Intra-rectal infusion of Curcuma longa extract was not able to minimize the inflammatory process or vascular congestion in the diversion colitis of rats subjected to colostomy.
Document Type: article
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ISSN: 0102-6720
DOI: 10.1590/0102-672020190001e1456
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  Data: EFFICACY OF CURCUMA LONGA IN THE TREATMENT OF DIVERSION COLITIS IN RATS
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  Data: <i>ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)</i>. January 2019 32(3)
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  Data: Colégio Brasileiro de Cirurgia Digestiva, 2019.
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  Data: <searchLink fieldCode="DE" term="%22Curcuma%2C+zingibereceae%22">Curcuma, zingibereceae</searchLink><br /><searchLink fieldCode="DE" term="%22Colite%22">Colite</searchLink><br /><searchLink fieldCode="DE" term="%22Anti-inflamatórios%22">Anti-inflamatórios</searchLink><br /><searchLink fieldCode="DE" term="%22Ratos%22">Ratos</searchLink><br /><searchLink fieldCode="DE" term="%22Colostomia%22">Colostomia</searchLink>
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  Data: Background: Diversion colitis is still very common in our country, since the stoma creation is a common practice especially in situations of trauma. needing treatment for this condition. Aim: To evaluate the therapeutic effect of rectal infusion of Curcuma longa (turmeric) in the excluded intestinal segment of rats. Method: Eighteen Wistar rats were used and submitted to colostomy: control group (n=8) under rectal saline infusion and group CL, receiving intra-rectal infusion of Curcuma longa extract (n=10). After 21 days of treatment they were submitted to euthanasia; the intestinal segment excluded from intestinal transit was resected and sent to histopathological evaluation, classifying the degree of inflammation and of vascular congestion. Results: The average of inflammation was 2.7 in the control group vs. 2.6 in the CL group (p=0.3125), while the mean vascular congestion was 2.3 and 2.1, respectively, in the control and CL groups (p=0.1642). Conclusion: Intra-rectal infusion of Curcuma longa extract was not able to minimize the inflammatory process or vascular congestion in the diversion colitis of rats subjected to colostomy.
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