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Investigação eletroquímica e calorimétrica da interação de novos agentes antitumorais biscatiônicos com DNA

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Title: Investigação eletroquímica e calorimétrica da interação de novos agentes antitumorais biscatiônicos com DNA
Authors: Silva, Láuris Lucia da, Donnici, Claudio Luis, Lopes, Júlio César Dias, Goulart, Marília Oliveira Fonseca, Abreu, Fabiane Caxico de, Paula, Francine Santos de, Bravo, Carlos E. Salas, Santoro, Marcelo Matos, Denadai, Ângelo Márcio Leite, Santos, Alexandre Martins Costa, Montanari, Carlos Alberto
Source: Química Nova. January 2012 35(7)
Publisher Information: Sociedade Brasileira de Química, 2012.
Publication Year: 2012
Subject Terms: biscationic compounds and interaction with DNA, isothermal titration calorimetry, electrochemical biosensor
More Details: Biscationic amidines bind in the DNA minor groove and present biological activity against a range of infectious diseases. Two new biscationic compounds (bis-α,ω-S-thioureido, amino and sulfide analogues) were synthesized in good yields and fully characterized, and their interaction with DNA was also investigated. Isothermal titration calorimetry (ITC) was used to measure the thermodynamic properties of binding interactions between DNA and these ligands. A double stranded calf thymus DNA immobilized on an electrode surface was used to study the possible DNA-interacting abilities of these compounds towards dsDNA in situ. A remarkable interaction of these compounds with DNA was demonstrated and their potential application as anticancer agents was furthered.
Document Type: article
File Description: text/html
Language: Portuguese
ISSN: 0100-4042
DOI: 10.1590/S0100-40422012000700007
Access URL: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000700007
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  Data: Investigação eletroquímica e calorimétrica da interação de novos agentes antitumorais biscatiônicos com DNA
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  Data: <searchLink fieldCode="AR" term="%22Silva%2C+Láuris+Lucia+da%22">Silva, Láuris Lucia da</searchLink><br /><searchLink fieldCode="AR" term="%22Donnici%2C+Claudio+Luis%22">Donnici, Claudio Luis</searchLink><br /><searchLink fieldCode="AR" term="%22Lopes%2C+Júlio+César+Dias%22">Lopes, Júlio César Dias</searchLink><br /><searchLink fieldCode="AR" term="%22Goulart%2C+Marília+Oliveira+Fonseca%22">Goulart, Marília Oliveira Fonseca</searchLink><br /><searchLink fieldCode="AR" term="%22Abreu%2C+Fabiane+Caxico+de%22">Abreu, Fabiane Caxico de</searchLink><br /><searchLink fieldCode="AR" term="%22Paula%2C+Francine+Santos+de%22">Paula, Francine Santos de</searchLink><br /><searchLink fieldCode="AR" term="%22Bravo%2C+Carlos+E%2E+Salas%22">Bravo, Carlos E. Salas</searchLink><br /><searchLink fieldCode="AR" term="%22Santoro%2C+Marcelo+Matos%22">Santoro, Marcelo Matos</searchLink><br /><searchLink fieldCode="AR" term="%22Denadai%2C+Ângelo+Márcio+Leite%22">Denadai, Ângelo Márcio Leite</searchLink><br /><searchLink fieldCode="AR" term="%22Santos%2C+Alexandre+Martins+Costa%22">Santos, Alexandre Martins Costa</searchLink><br /><searchLink fieldCode="AR" term="%22Montanari%2C+Carlos+Alberto%22">Montanari, Carlos Alberto</searchLink>
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  Data: <i>Química Nova</i>. January 2012 35(7)
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  Data: Sociedade Brasileira de Química, 2012.
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  Data: Biscationic amidines bind in the DNA minor groove and present biological activity against a range of infectious diseases. Two new biscationic compounds (bis-α,ω-S-thioureido, amino and sulfide analogues) were synthesized in good yields and fully characterized, and their interaction with DNA was also investigated. Isothermal titration calorimetry (ITC) was used to measure the thermodynamic properties of binding interactions between DNA and these ligands. A double stranded calf thymus DNA immobilized on an electrode surface was used to study the possible DNA-interacting abilities of these compounds towards dsDNA in situ. A remarkable interaction of these compounds with DNA was demonstrated and their potential application as anticancer agents was furthered.
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  Data: 10.1590/S0100-40422012000700007
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      – SubjectFull: biscationic compounds and interaction with DNA
        Type: general
      – SubjectFull: isothermal titration calorimetry
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