Method of Identifying Modulators of NOGO-Functions
| Title: | Method of Identifying Modulators of NOGO-Functions |
|---|---|
| Document Number: | 20070286851 |
| Publication Date: | December 13, 2007 |
| Appl. No: | 11/836887 |
| Application Filed: | August 10, 2007 |
| Abstract: | Methods of treating acute neuronal injury by utilizing a BACE polypeptide that binds to Nogo, or compositions comprising such BACE polypeptide. Additional methods of treating a neoplastic, hyperproliferative or dysproliferative disorder, utilizing a BACE polypeptide that binds to Nogo, or compositions comprising such BACE polypeptide |
| Inventors: | BLACKSTOCK, Walter Philip (Stevenage, GB); HALE, Richard Stephen (Stevenage, GB); PRINJHA, Rabinder (Harlow, GB); ROWLEY, Adele (Stevenage, GB) |
| Assignees: | GLAXO GROUP LIMITED (Greenford, GB), SMITHKLINE BEECHAM PLC. (Brentford, GB) |
| Claim: | 1-15. (canceled) |
| Claim: | 16. A method of treatment of acute neuronal injury, which method comprises administering an effective amount of a BACE polypeptide, to a human or animal in need of such treatment wherein said BACE polypeptide binds to Nogo. |
| Claim: | 17. (canceled) |
| Claim: | 18. A method according to claim 16 wherein said acute neuronal injury is selected from spinal injury, stroke, brain injury and peripheral nervous system damage. |
| Claim: | 19. (canceled) |
| Claim: | 20. A composition comprising a BACE polypeptide, or a polynucleotide encoding a BACE polyeptide wherein said BACE polypeptide binds Nogo, and a pharmaceutically acceptable carrier or diluent. |
| Claim: | 21. A method of treatment of a neoplastic, hyperproliferative or dysproliferative disorder, which method comprises administering an effective amount of a BACE polypeptide, a polynucleotide encoding a BACE to a human or animal in need of such treatment wherein said BACE polypeptide binds Nogo. |
| Claim: | 22. (canceled) |
| Claim: | 23. A method according to claim 21 wherein said neoplastic, hyperproliferative or dysproliferative disorder is a disorder of the central nervous system. |
| Claim: | 24. A method according to claim 16 wherein said BACE polypeptide is selected from SEQ ID NO:2 and SEQ ID NO:13. |
| Claim: | 25. A composition according to claim 20 wherein said BACE polypeptide is selected from SEQ ID NO:2 and SEQ ID NO:13. |
| Claim: | 26. A method according to claim 21 wherein said BACE polypeptide is selected from SEQ ID NO:2 and SEQ ID NO:13. |
| Current U.S. Class: | 424094/660 |
| Current International Class: | 61; 61; 61; 61 |
| Accession Number: | edspap.20070286851 |
| Database: | USPTO Patent Applications |
| FullText | Text: Availability: 0 CustomLinks: – Url: https://ppubs.uspto.gov/pubwebapp/external.html?q=(%2220070286851%22).pn.&db=US-PGPUB&type=ids Name: EDS - USPTO Patent Applications Category: fullText Text: View record from USPTO MouseOverText: View record from USPTO – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edspap&genre=article&issn=&ISBN=&volume=&issue=&date=20071213&spage=&pages=&title=Method of Identifying Modulators of NOGO-Functions&atitle=Method%20of%20Identifying%20Modulators%20of%20NOGO-Functions&aulast=BLACKSTOCK%2C%20Walter%20Philip&id=DOI: Name: Full Text Finder (for New FTF UI) (s8985755) Category: fullText Text: Find It @ SCU Libraries MouseOverText: Find It @ SCU Libraries |
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| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Method of Identifying Modulators of NOGO-Functions – Name: DocumentID Label: Document Number Group: Patent Data: 20070286851 – Name: DateEntry Label: Publication Date Group: Patent Data: December 13, 2007 – Name: DocumentID Label: Appl. No Group: Patent Data: 11/836887 – Name: DateFiled Label: Application Filed Group: Patent Data: August 10, 2007 – Name: Abstract Label: Abstract Group: Ab Data: Methods of treating acute neuronal injury by utilizing a BACE polypeptide that binds to Nogo, or compositions comprising such BACE polypeptide. Additional methods of treating a neoplastic, hyperproliferative or dysproliferative disorder, utilizing a BACE polypeptide that binds to Nogo, or compositions comprising such BACE polypeptide – Name: Author Label: Inventors Group: Patent Data: <searchLink fieldCode="ZA" term="%22BLACKSTOCK%2C+Walter+Philip%22">BLACKSTOCK, Walter Philip</searchLink> (Stevenage, GB); <searchLink fieldCode="ZA" term="%22HALE%2C+Richard+Stephen%22">HALE, Richard Stephen</searchLink> (Stevenage, GB); <searchLink fieldCode="ZA" term="%22PRINJHA%2C+Rabinder%22">PRINJHA, Rabinder</searchLink> (Harlow, GB); <searchLink fieldCode="ZA" term="%22ROWLEY%2C+Adele%22">ROWLEY, Adele</searchLink> (Stevenage, GB) – Name: OtherAuthors Label: Assignees Group: Patent Data: <searchLink fieldCode="ZS" term="%22GLAXO+GROUP+LIMITED%22">GLAXO GROUP LIMITED</searchLink> (Greenford, GB), <searchLink fieldCode="ZS" term="%22SMITHKLINE+BEECHAM+PLC%2E%22">SMITHKLINE BEECHAM PLC.</searchLink> (Brentford, GB) – Name: Comment Label: Claim Group: Patent Data: 1-15. (canceled) – Name: Comment Label: Claim Group: Patent Data: 16. A method of treatment of acute neuronal injury, which method comprises administering an effective amount of a BACE polypeptide, to a human or animal in need of such treatment wherein said BACE polypeptide binds to Nogo. – Name: Comment Label: Claim Group: Patent Data: 17. (canceled) – Name: Comment Label: Claim Group: Patent Data: 18. A method according to claim 16 wherein said acute neuronal injury is selected from spinal injury, stroke, brain injury and peripheral nervous system damage. – Name: Comment Label: Claim Group: Patent Data: 19. (canceled) – Name: Comment Label: Claim Group: Patent Data: 20. A composition comprising a BACE polypeptide, or a polynucleotide encoding a BACE polyeptide wherein said BACE polypeptide binds Nogo, and a pharmaceutically acceptable carrier or diluent. – Name: Comment Label: Claim Group: Patent Data: 21. A method of treatment of a neoplastic, hyperproliferative or dysproliferative disorder, which method comprises administering an effective amount of a BACE polypeptide, a polynucleotide encoding a BACE to a human or animal in need of such treatment wherein said BACE polypeptide binds Nogo. – Name: Comment Label: Claim Group: Patent Data: 22. (canceled) – Name: Comment Label: Claim Group: Patent Data: 23. A method according to claim 21 wherein said neoplastic, hyperproliferative or dysproliferative disorder is a disorder of the central nervous system. – Name: Comment Label: Claim Group: Patent Data: 24. A method according to claim 16 wherein said BACE polypeptide is selected from SEQ ID NO:2 and SEQ ID NO:13. – Name: Comment Label: Claim Group: Patent Data: 25. A composition according to claim 20 wherein said BACE polypeptide is selected from SEQ ID NO:2 and SEQ ID NO:13. – Name: Comment Label: Claim Group: Patent Data: 26. A method according to claim 21 wherein said BACE polypeptide is selected from SEQ ID NO:2 and SEQ ID NO:13. – Name: CodeClass Label: Current U.S. Class Group: Patent Data: 424094/660 – Name: CodeClass Label: Current International Class Group: Patent Data: 61; 61; 61; 61 – Name: AN Label: Accession Number Group: ID Data: edspap.20070286851 |
| PLink | https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edspap&AN=edspap.20070286851 |
| RecordInfo | BibRecord: BibEntity: Languages: – Text: English Titles: – TitleFull: Method of Identifying Modulators of NOGO-Functions Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: BLACKSTOCK, Walter Philip – PersonEntity: Name: NameFull: HALE, Richard Stephen – PersonEntity: Name: NameFull: PRINJHA, Rabinder – PersonEntity: Name: NameFull: ROWLEY, Adele IsPartOfRelationships: – BibEntity: Dates: – D: 13 M: 12 Text: December 13, 2007 Type: published Y: 2007 |
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