Bibliographic Details
| Title: |
Method of Identifying Modulators of NOGO-Functions |
| Document Number: |
20070286851 |
| Publication Date: |
December 13, 2007 |
| Appl. No: |
11/836887 |
| Application Filed: |
August 10, 2007 |
| Abstract: |
Methods of treating acute neuronal injury by utilizing a BACE polypeptide that binds to Nogo, or compositions comprising such BACE polypeptide. Additional methods of treating a neoplastic, hyperproliferative or dysproliferative disorder, utilizing a BACE polypeptide that binds to Nogo, or compositions comprising such BACE polypeptide |
| Inventors: |
BLACKSTOCK, Walter Philip (Stevenage, GB); HALE, Richard Stephen (Stevenage, GB); PRINJHA, Rabinder (Harlow, GB); ROWLEY, Adele (Stevenage, GB) |
| Assignees: |
GLAXO GROUP LIMITED (Greenford, GB), SMITHKLINE BEECHAM PLC. (Brentford, GB) |
| Claim: |
1-15. (canceled) |
| Claim: |
16. A method of treatment of acute neuronal injury, which method comprises administering an effective amount of a BACE polypeptide, to a human or animal in need of such treatment wherein said BACE polypeptide binds to Nogo. |
| Claim: |
17. (canceled) |
| Claim: |
18. A method according to claim 16 wherein said acute neuronal injury is selected from spinal injury, stroke, brain injury and peripheral nervous system damage. |
| Claim: |
19. (canceled) |
| Claim: |
20. A composition comprising a BACE polypeptide, or a polynucleotide encoding a BACE polyeptide wherein said BACE polypeptide binds Nogo, and a pharmaceutically acceptable carrier or diluent. |
| Claim: |
21. A method of treatment of a neoplastic, hyperproliferative or dysproliferative disorder, which method comprises administering an effective amount of a BACE polypeptide, a polynucleotide encoding a BACE to a human or animal in need of such treatment wherein said BACE polypeptide binds Nogo. |
| Claim: |
22. (canceled) |
| Claim: |
23. A method according to claim 21 wherein said neoplastic, hyperproliferative or dysproliferative disorder is a disorder of the central nervous system. |
| Claim: |
24. A method according to claim 16 wherein said BACE polypeptide is selected from SEQ ID NO:2 and SEQ ID NO:13. |
| Claim: |
25. A composition according to claim 20 wherein said BACE polypeptide is selected from SEQ ID NO:2 and SEQ ID NO:13. |
| Claim: |
26. A method according to claim 21 wherein said BACE polypeptide is selected from SEQ ID NO:2 and SEQ ID NO:13. |
| Current U.S. Class: |
424094/660 |
| Current International Class: |
61; 61; 61; 61 |
| Accession Number: |
edspap.20070286851 |
| Database: |
USPTO Patent Applications |
