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AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A

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Title: AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A
Authors: Alexandra K. Davies, Daniel N. Itzhak, James R. Edgar, Tara L. Archuleta, Jennifer Hirst, Lauren P. Jackson, Margaret S. Robinson, Georg H. H. Borner
Source: Nature Communications, Vol 9, Iss 1, Pp 1-21 (2018)
Publisher Information: Nature Portfolio, 2018.
Publication Year: 2018
Collection: LCC:Science
Subject Terms: Science
More Details: Adaptor protein complex 4 (AP-4) deficiency causes a severe neurological disorder via an unknown mechanism. Here, the authors reveal cargo and machinery of the AP-4 transport pathway, and propose that AP-4 mediates spatial regulation of autophagy through peripheral delivery of ATG9A.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2041-1723
Relation: https://doaj.org/toc/2041-1723
DOI: 10.1038/s41467-018-06172-7
Access URL: https://doaj.org/article/ff52a2aa9d09459f8fa30ecd00dc3289
Accession Number: edsdoj.ff52a2aa9d09459f8fa30ecd00dc3289
Database: Directory of Open Access Journals
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  Data: Adaptor protein complex 4 (AP-4) deficiency causes a severe neurological disorder via an unknown mechanism. Here, the authors reveal cargo and machinery of the AP-4 transport pathway, and propose that AP-4 mediates spatial regulation of autophagy through peripheral delivery of ATG9A.
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