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Pre‐Crosslinking with Hydrogel Microparticles Enhances the Printability of Alginate‐Based Inks

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Title: Pre‐Crosslinking with Hydrogel Microparticles Enhances the Printability of Alginate‐Based Inks
Authors: Jonas Hazur, Jonas Röder, Jonas Czwalinna, Dirk W. Schubert, Aldo R. Boccaccini
Source: Macromolecular Materials and Engineering, Vol 308, Iss 12, Pp n/a-n/a (2023)
Publisher Information: Wiley-VCH, 2023.
Publication Year: 2023
Collection: LCC:Materials of engineering and construction. Mechanics of materials
LCC:Engineering (General). Civil engineering (General)
Subject Terms: alginate, bioprinting, cross‐linking, gelatin, oxidized alginate, Materials of engineering and construction. Mechanics of materials, TA401-492, Engineering (General). Civil engineering (General), TA1-2040
More Details: Abstract The main challenge in extrusion‐based bioprinting is to develop inks which must comprise a manifold of characteristics before, during, and after printing. To tackle the challenge of good shape fidelity and printability of low concentration inks, in this study hydrogel microparticles (HMPs) are proposed to produce internally pre‐crosslinked inks. Alginate (Alg) and oxidized alginate (OA)‐based HMPs are fabricated and used as Ca2+‐releasing reservoirs. OA HMPs are used to demonstrate the versatility of this approach and to show its suitability also for chemically modified alginate. Embedded in either fresh Alg or OA solution, HMPs are used to pre‐crosslink the inks. Rheological measurements revealed that HMP pre‐crosslinking increases the yield stress and viscosity while reducing the loss angle of bioinks. Moreover, printing experiments reveal that being able to tailor rheological properties is an effective tool to improve printability. Furthermore, pre‐crosslinking significantly alters the hydogel internal microstructure. In vitro studies show that NIH/3T3 cells proliferate in HMP pre‐crosslinked bioinks modified with gelatin. Altogether, a low‐cost and easy to use setup to prepare HMPs is presented and for the first time, the possibility of using such HMPs as pre‐crosslinking agent to tailor the printability of alginate‐based bioinks is demonstrated.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1439-2054
1438-7492
Relation: https://doaj.org/toc/1438-7492; https://doaj.org/toc/1439-2054
DOI: 10.1002/mame.202200675
Access URL: https://doaj.org/article/fdc7e5d09d6d44cb835a86d22d4d2f49
Accession Number: edsdoj.fdc7e5d09d6d44cb835a86d22d4d2f49
Database: Directory of Open Access Journals
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  Data: Pre‐Crosslinking with Hydrogel Microparticles Enhances the Printability of Alginate‐Based Inks
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  Data: Macromolecular Materials and Engineering, Vol 308, Iss 12, Pp n/a-n/a (2023)
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  Data: 2023
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  Data: LCC:Materials of engineering and construction. Mechanics of materials<br />LCC:Engineering (General). Civil engineering (General)
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  Data: <searchLink fieldCode="DE" term="%22alginate%22">alginate</searchLink><br /><searchLink fieldCode="DE" term="%22bioprinting%22">bioprinting</searchLink><br /><searchLink fieldCode="DE" term="%22cross‐linking%22">cross‐linking</searchLink><br /><searchLink fieldCode="DE" term="%22gelatin%22">gelatin</searchLink><br /><searchLink fieldCode="DE" term="%22oxidized+alginate%22">oxidized alginate</searchLink><br /><searchLink fieldCode="DE" term="%22Materials+of+engineering+and+construction%2E+Mechanics+of+materials%22">Materials of engineering and construction. Mechanics of materials</searchLink><br /><searchLink fieldCode="DE" term="%22TA401-492%22">TA401-492</searchLink><br /><searchLink fieldCode="DE" term="%22Engineering+%28General%29%2E+Civil+engineering+%28General%29%22">Engineering (General). Civil engineering (General)</searchLink><br /><searchLink fieldCode="DE" term="%22TA1-2040%22">TA1-2040</searchLink>
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  Data: Abstract The main challenge in extrusion‐based bioprinting is to develop inks which must comprise a manifold of characteristics before, during, and after printing. To tackle the challenge of good shape fidelity and printability of low concentration inks, in this study hydrogel microparticles (HMPs) are proposed to produce internally pre‐crosslinked inks. Alginate (Alg) and oxidized alginate (OA)‐based HMPs are fabricated and used as Ca2+‐releasing reservoirs. OA HMPs are used to demonstrate the versatility of this approach and to show its suitability also for chemically modified alginate. Embedded in either fresh Alg or OA solution, HMPs are used to pre‐crosslink the inks. Rheological measurements revealed that HMP pre‐crosslinking increases the yield stress and viscosity while reducing the loss angle of bioinks. Moreover, printing experiments reveal that being able to tailor rheological properties is an effective tool to improve printability. Furthermore, pre‐crosslinking significantly alters the hydogel internal microstructure. In vitro studies show that NIH/3T3 cells proliferate in HMP pre‐crosslinked bioinks modified with gelatin. Altogether, a low‐cost and easy to use setup to prepare HMPs is presented and for the first time, the possibility of using such HMPs as pre‐crosslinking agent to tailor the printability of alginate‐based bioinks is demonstrated.
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        Value: 10.1002/mame.202200675
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      – Text: English
    Subjects:
      – SubjectFull: alginate
        Type: general
      – SubjectFull: bioprinting
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      – SubjectFull: cross‐linking
        Type: general
      – SubjectFull: gelatin
        Type: general
      – SubjectFull: oxidized alginate
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      – TitleFull: Pre‐Crosslinking with Hydrogel Microparticles Enhances the Printability of Alginate‐Based Inks
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