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The Preventive Effect of Theabrownin from Ya’an Tibetan Tea Against UVB-Induced Skin Photodamage in BALB/c Mice via the MAPK/NF-κB and Nrf2 Signaling Pathways

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Title: The Preventive Effect of Theabrownin from Ya’an Tibetan Tea Against UVB-Induced Skin Photodamage in BALB/c Mice via the MAPK/NF-κB and Nrf2 Signaling Pathways
Authors: Jingyi Xu, Mingji Xie, Xing Liang, Peida Luo, Xinyao Yang, Jing Zhao, Jinlin Bian, Bo Sun, Qian Tang, Xiao Du, Yao Zou, Weidong Dai, Chunlei He
Source: Foods, Vol 14, Iss 4, p 600 (2025)
Publisher Information: MDPI AG, 2025.
Publication Year: 2025
Collection: LCC:Chemical technology
Subject Terms: theabrownin, Tibetan tea, photodamage, antioxidant, anti-inflammation, apoptosis, Chemical technology, TP1-1185
More Details: Ya’an Tibetan tea, renowned as a mysterious tea, has been used as a traditional remedy for disease prevention among ethnic minorities in the Qinghai-Tibet Plateau region, which experiences the highest levels of UVB radiation in the world, for over 1000 years. Theabrownin (TB) from Ya’an Tibetan tea exhibits various health benefits. In this study, the preventive effects of TB on UVB-induced skin damage were investigated. The results showed that TB pretreatment significantly alleviated visible skin damage, epidermal hyperplasia, and collagen destruction in BALB/c mice. The mechanism of action involved increasing the mRNA and protein levels of Nrf2 and enhancing SOD enzyme activity, thereby reducing MDA content and improving the body’s antioxidant capacity. TB also inhibited the protein synthesis of inflammatory factors such as TNF-α, IL-1β, and IL-6, as well as the expression of NF-κB mRNA and protein, thereby reducing skin inflammation. Furthermore, it suppressed the overexpression of p38 MAPK, ERK, and AP-1 mRNA and protein, along with the downstream MMP-1 protein, to prevent collagen destruction in the skin. Additionally, TB pretreatment prevented cell apoptosis by reducing Caspase-3 overexpression. These results suggest that TB can prevent UVB-induced photodamage and exert its preventive effects in a dose-dependent manner by downregulating the MAPK/NF-κB signaling pathway while promoting the Nrf2 signaling pathway in the skin. Consequently, TB holds promising potential for future applications in skin photodamage prevention and skin health promotion.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2304-8158
Relation: https://www.mdpi.com/2304-8158/14/4/600; https://doaj.org/toc/2304-8158
DOI: 10.3390/foods14040600
Access URL: https://doaj.org/article/fc37c43135614677b7bad81c071d83d9
Accession Number: edsdoj.fc37c43135614677b7bad81c071d83d9
Database: Directory of Open Access Journals
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  Data: The Preventive Effect of Theabrownin from Ya’an Tibetan Tea Against UVB-Induced Skin Photodamage in BALB/c Mice via the MAPK/NF-κB and Nrf2 Signaling Pathways
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  Data: Foods, Vol 14, Iss 4, p 600 (2025)
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  Data: Ya’an Tibetan tea, renowned as a mysterious tea, has been used as a traditional remedy for disease prevention among ethnic minorities in the Qinghai-Tibet Plateau region, which experiences the highest levels of UVB radiation in the world, for over 1000 years. Theabrownin (TB) from Ya’an Tibetan tea exhibits various health benefits. In this study, the preventive effects of TB on UVB-induced skin damage were investigated. The results showed that TB pretreatment significantly alleviated visible skin damage, epidermal hyperplasia, and collagen destruction in BALB/c mice. The mechanism of action involved increasing the mRNA and protein levels of Nrf2 and enhancing SOD enzyme activity, thereby reducing MDA content and improving the body’s antioxidant capacity. TB also inhibited the protein synthesis of inflammatory factors such as TNF-α, IL-1β, and IL-6, as well as the expression of NF-κB mRNA and protein, thereby reducing skin inflammation. Furthermore, it suppressed the overexpression of p38 MAPK, ERK, and AP-1 mRNA and protein, along with the downstream MMP-1 protein, to prevent collagen destruction in the skin. Additionally, TB pretreatment prevented cell apoptosis by reducing Caspase-3 overexpression. These results suggest that TB can prevent UVB-induced photodamage and exert its preventive effects in a dose-dependent manner by downregulating the MAPK/NF-κB signaling pathway while promoting the Nrf2 signaling pathway in the skin. Consequently, TB holds promising potential for future applications in skin photodamage prevention and skin health promotion.
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        StartPage: 600
    Subjects:
      – SubjectFull: theabrownin
        Type: general
      – SubjectFull: Tibetan tea
        Type: general
      – SubjectFull: photodamage
        Type: general
      – SubjectFull: antioxidant
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      – TitleFull: The Preventive Effect of Theabrownin from Ya’an Tibetan Tea Against UVB-Induced Skin Photodamage in BALB/c Mice via the MAPK/NF-κB and Nrf2 Signaling Pathways
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