Academic Journal
View in EDS

Cerebrovascular Events in Patients Undergoing Transfemoral Transcatheter Aortic Valve Implantation: A Pooled Patient‐Level Study

Bibliographic Details
Title: Cerebrovascular Events in Patients Undergoing Transfemoral Transcatheter Aortic Valve Implantation: A Pooled Patient‐Level Study
Authors: Astrid C. van Nieuwkerk, Hugo M. Aarts, Kimberley I. Hemelrijk, Cristobal Urbano Carrillo, Didier Tchétché, Fabio S. de Brito, Marco Barbanti, Ran Kornowski, Azeem Latib, Augusto D'Onofrio, Flavio Ribichini, Sergio García‐Blas, Nicolas Dumonteil, Alexandre Abizaid, Samantha Sartori, Paola D'Errigo, Giuseppe Tarantini, Mattia Lunardi, Katia Orvin, Matteo Pagnesi, Felipe Navarro, George Dangas, Roxana Mehran, Ronak Delewi
Source: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 17 (2024)
Publisher Information: Wiley, 2024.
Publication Year: 2024
Collection: LCC:Diseases of the circulatory (Cardiovascular) system
Subject Terms: aortic valve stenosis, mortality, stroke, transcatheter aortic valve replacement, Diseases of the circulatory (Cardiovascular) system, RC666-701
More Details: Background Cerebrovascular events remain one of the most devastating complications of transcatheter aortic valve implantation (TAVI). Data from real‐world contemporary cohorts on longitudinal trends and outcomes remain limited. The aim of this study was to assess incidence, temporal trends, predictors, and outcomes of cerebrovascular events following transfemoral TAVI. Methods and Results The CENTER2 (Cerebrovascular Events in Patients Undergoing Transcatheter Aortic Valve Implantation With Balloon‐Expandable Valves Versus Self‐Expandable Valves 2) study includes patients undergoing TAVI between 2007 and 2022. The database contains pooled patient‐level data from 10 clinical studies. A total of 24 305 patients underwent transfemoral TAVI (mean age 81.5±6.7 years, 56% women, median Society of Thoracic Surgeon Predicted Risk of Mortality 4.9% [3.1%–8.5%]). Of these patients, 2.2% (n=534) experienced stroke in the first 30 days after TAVI, and 40 (0.4%) had a transient ischemic attack. Stroke rates remained stable during the treatment period (2007–2010: 2.1%, 2011–2014: 2.5%, 2015–2018: 2.1%, 2019–2022: 2.1%; Ptrend=0.28). Moreover, 30‐day cerebrovascular event rates were similar across Society of Thoracic Surgeon Predicted Risk of Mortality risk categories: 2.1% in low‐risk, 2.6% in intermediate‐risk, and 2.5% in high‐risk patients (P=0.21). Mortality was higher in patients with 30‐day stroke than without at 30 days (20.3% versus 4.7%; odds ratio, 5.1 [95% CI, 4.1–6.5]; P
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2047-9980
Relation: https://doaj.org/toc/2047-9980
DOI: 10.1161/JAHA.123.032901
Access URL: https://doaj.org/article/dfc0db0abb1345f1998bb5a413dd6a3c
Accession Number: edsdoj.fc0db0abb1345f1998bb5a413dd6a3c
Database: Directory of Open Access Journals
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edsdoj&genre=article&issn=20479980&ISBN=&volume=13&issue=17&date=20240901&spage=&pages=&title=Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease&atitle=Cerebrovascular%20Events%20in%20Patients%20Undergoing%20Transfemoral%20Transcatheter%20Aortic%20Valve%20Implantation%3A%20A%20Pooled%20Patient%E2%80%90Level%20Study&aulast=Astrid%20C.%20van%20Nieuwkerk&id=DOI:10.1161/JAHA.123.032901
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
  – Url: https://doaj.org/article/dfc0db0abb1345f1998bb5a413dd6a3c
    Name: EDS - DOAJ (s8985755)
    Category: fullText
    Text: View record from DOAJ
    MouseOverText: View record from DOAJ
Header DbId: edsdoj
DbLabel: Directory of Open Access Journals
An: edsdoj.fc0db0abb1345f1998bb5a413dd6a3c
RelevancyScore: 1022
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 1022.25531005859
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Cerebrovascular Events in Patients Undergoing Transfemoral Transcatheter Aortic Valve Implantation: A Pooled Patient‐Level Study
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Astrid+C%2E+van+Nieuwkerk%22">Astrid C. van Nieuwkerk</searchLink><br /><searchLink fieldCode="AR" term="%22Hugo+M%2E+Aarts%22">Hugo M. Aarts</searchLink><br /><searchLink fieldCode="AR" term="%22Kimberley+I%2E+Hemelrijk%22">Kimberley I. Hemelrijk</searchLink><br /><searchLink fieldCode="AR" term="%22Cristobal+Urbano+Carrillo%22">Cristobal Urbano Carrillo</searchLink><br /><searchLink fieldCode="AR" term="%22Didier+Tchétché%22">Didier Tchétché</searchLink><br /><searchLink fieldCode="AR" term="%22Fabio+S%2E+de+Brito%22">Fabio S. de Brito</searchLink><br /><searchLink fieldCode="AR" term="%22Marco+Barbanti%22">Marco Barbanti</searchLink><br /><searchLink fieldCode="AR" term="%22Ran+Kornowski%22">Ran Kornowski</searchLink><br /><searchLink fieldCode="AR" term="%22Azeem+Latib%22">Azeem Latib</searchLink><br /><searchLink fieldCode="AR" term="%22Augusto+D'Onofrio%22">Augusto D'Onofrio</searchLink><br /><searchLink fieldCode="AR" term="%22Flavio+Ribichini%22">Flavio Ribichini</searchLink><br /><searchLink fieldCode="AR" term="%22Sergio+García‐Blas%22">Sergio García‐Blas</searchLink><br /><searchLink fieldCode="AR" term="%22Nicolas+Dumonteil%22">Nicolas Dumonteil</searchLink><br /><searchLink fieldCode="AR" term="%22Alexandre+Abizaid%22">Alexandre Abizaid</searchLink><br /><searchLink fieldCode="AR" term="%22Samantha+Sartori%22">Samantha Sartori</searchLink><br /><searchLink fieldCode="AR" term="%22Paola+D'Errigo%22">Paola D'Errigo</searchLink><br /><searchLink fieldCode="AR" term="%22Giuseppe+Tarantini%22">Giuseppe Tarantini</searchLink><br /><searchLink fieldCode="AR" term="%22Mattia+Lunardi%22">Mattia Lunardi</searchLink><br /><searchLink fieldCode="AR" term="%22Katia+Orvin%22">Katia Orvin</searchLink><br /><searchLink fieldCode="AR" term="%22Matteo+Pagnesi%22">Matteo Pagnesi</searchLink><br /><searchLink fieldCode="AR" term="%22Felipe+Navarro%22">Felipe Navarro</searchLink><br /><searchLink fieldCode="AR" term="%22George+Dangas%22">George Dangas</searchLink><br /><searchLink fieldCode="AR" term="%22Roxana+Mehran%22">Roxana Mehran</searchLink><br /><searchLink fieldCode="AR" term="%22Ronak+Delewi%22">Ronak Delewi</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 17 (2024)
– Name: Publisher
  Label: Publisher Information
  Group: PubInfo
  Data: Wiley, 2024.
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2024
– Name: Subset
  Label: Collection
  Group: HoldingsInfo
  Data: LCC:Diseases of the circulatory (Cardiovascular) system
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22aortic+valve+stenosis%22">aortic valve stenosis</searchLink><br /><searchLink fieldCode="DE" term="%22mortality%22">mortality</searchLink><br /><searchLink fieldCode="DE" term="%22stroke%22">stroke</searchLink><br /><searchLink fieldCode="DE" term="%22transcatheter+aortic+valve+replacement%22">transcatheter aortic valve replacement</searchLink><br /><searchLink fieldCode="DE" term="%22Diseases+of+the+circulatory+%28Cardiovascular%29+system%22">Diseases of the circulatory (Cardiovascular) system</searchLink><br /><searchLink fieldCode="DE" term="%22RC666-701%22">RC666-701</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Background Cerebrovascular events remain one of the most devastating complications of transcatheter aortic valve implantation (TAVI). Data from real‐world contemporary cohorts on longitudinal trends and outcomes remain limited. The aim of this study was to assess incidence, temporal trends, predictors, and outcomes of cerebrovascular events following transfemoral TAVI. Methods and Results The CENTER2 (Cerebrovascular Events in Patients Undergoing Transcatheter Aortic Valve Implantation With Balloon‐Expandable Valves Versus Self‐Expandable Valves 2) study includes patients undergoing TAVI between 2007 and 2022. The database contains pooled patient‐level data from 10 clinical studies. A total of 24 305 patients underwent transfemoral TAVI (mean age 81.5±6.7 years, 56% women, median Society of Thoracic Surgeon Predicted Risk of Mortality 4.9% [3.1%–8.5%]). Of these patients, 2.2% (n=534) experienced stroke in the first 30 days after TAVI, and 40 (0.4%) had a transient ischemic attack. Stroke rates remained stable during the treatment period (2007–2010: 2.1%, 2011–2014: 2.5%, 2015–2018: 2.1%, 2019–2022: 2.1%; Ptrend=0.28). Moreover, 30‐day cerebrovascular event rates were similar across Society of Thoracic Surgeon Predicted Risk of Mortality risk categories: 2.1% in low‐risk, 2.6% in intermediate‐risk, and 2.5% in high‐risk patients (P=0.21). Mortality was higher in patients with 30‐day stroke than without at 30 days (20.3% versus 4.7%; odds ratio, 5.1 [95% CI, 4.1–6.5]; P
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: article
– Name: Format
  Label: File Description
  Group: SrcInfo
  Data: electronic resource
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: ISSN
  Label: ISSN
  Group: ISSN
  Data: 2047-9980
– Name: NoteTitleSource
  Label: Relation
  Group: SrcInfo
  Data: https://doaj.org/toc/2047-9980
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1161/JAHA.123.032901
– Name: URL
  Label: Access URL
  Group: URL
  Data: <link linkTarget="URL" linkTerm="https://doaj.org/article/dfc0db0abb1345f1998bb5a413dd6a3c" linkWindow="_blank">https://doaj.org/article/dfc0db0abb1345f1998bb5a413dd6a3c</link>
– Name: AN
  Label: Accession Number
  Group: ID
  Data: edsdoj.fc0db0abb1345f1998bb5a413dd6a3c
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsdoj&AN=edsdoj.fc0db0abb1345f1998bb5a413dd6a3c
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1161/JAHA.123.032901
    Languages:
      – Text: English
    Subjects:
      – SubjectFull: aortic valve stenosis
        Type: general
      – SubjectFull: mortality
        Type: general
      – SubjectFull: stroke
        Type: general
      – SubjectFull: transcatheter aortic valve replacement
        Type: general
      – SubjectFull: Diseases of the circulatory (Cardiovascular) system
        Type: general
      – SubjectFull: RC666-701
        Type: general
    Titles:
      – TitleFull: Cerebrovascular Events in Patients Undergoing Transfemoral Transcatheter Aortic Valve Implantation: A Pooled Patient‐Level Study
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Astrid C. van Nieuwkerk
      – PersonEntity:
          Name:
            NameFull: Hugo M. Aarts
      – PersonEntity:
          Name:
            NameFull: Kimberley I. Hemelrijk
      – PersonEntity:
          Name:
            NameFull: Cristobal Urbano Carrillo
      – PersonEntity:
          Name:
            NameFull: Didier Tchétché
      – PersonEntity:
          Name:
            NameFull: Fabio S. de Brito
      – PersonEntity:
          Name:
            NameFull: Marco Barbanti
      – PersonEntity:
          Name:
            NameFull: Ran Kornowski
      – PersonEntity:
          Name:
            NameFull: Azeem Latib
      – PersonEntity:
          Name:
            NameFull: Augusto D'Onofrio
      – PersonEntity:
          Name:
            NameFull: Flavio Ribichini
      – PersonEntity:
          Name:
            NameFull: Sergio García‐Blas
      – PersonEntity:
          Name:
            NameFull: Nicolas Dumonteil
      – PersonEntity:
          Name:
            NameFull: Alexandre Abizaid
      – PersonEntity:
          Name:
            NameFull: Samantha Sartori
      – PersonEntity:
          Name:
            NameFull: Paola D'Errigo
      – PersonEntity:
          Name:
            NameFull: Giuseppe Tarantini
      – PersonEntity:
          Name:
            NameFull: Mattia Lunardi
      – PersonEntity:
          Name:
            NameFull: Katia Orvin
      – PersonEntity:
          Name:
            NameFull: Matteo Pagnesi
      – PersonEntity:
          Name:
            NameFull: Felipe Navarro
      – PersonEntity:
          Name:
            NameFull: George Dangas
      – PersonEntity:
          Name:
            NameFull: Roxana Mehran
      – PersonEntity:
          Name:
            NameFull: Ronak Delewi
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 09
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-print
              Value: 20479980
          Numbering:
            – Type: volume
              Value: 13
            – Type: issue
              Value: 17
          Titles:
            – TitleFull: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
              Type: main
ResultId 1