Academic Journal
View in EDS

Study protocol for the COPE study: COVID-19 in Older PEople: the influence of frailty and multimorbidity on survival. A multicentre, European observational study

Bibliographic Details
Title: Study protocol for the COPE study: COVID-19 in Older PEople: the influence of frailty and multimorbidity on survival. A multicentre, European observational study
Authors: Thomas Lee, Sandeep Singh, Phyo Kyaw Myint, Sheila Jones, Ben Carter, Susan Moug, Terry Quinn, Michael Thomas, Emma Bhatti, Angeline Price, Fenella Barlow-Pay, Siobhan Duffy, Lyndsay Pearce, Arturo Vilches-Moraga, Michael Stechman, Philip Braude, Emma Mitchell, Alessia Verduri, Kathryn McCarthy, Jonathan Hewitt, Charlotte Davey, Kiah Lunstone, Alice Cavenagh, Charlotte Silver, Thomas Telford, Rebecca Simmons, Dolcie Paxton, Francis Rickard, Mark Holloway, James Hesford, Tarik Jichi, Norman Galbraith, Jenny Edwards, Carly Bisset, Ross Alexander, Abigail Ingham, Roxanna Short, Aine McGovern, Jemima Collins, Eilidh Bruce, Alice Einarsson, Enrico Clini, Giovanni Guaraldi, Madeline Garcia, Shefali Sangani, Thomas Kneen, George Kyriakopoulos, Denise Tan
Source: BMJ Open, Vol 10, Iss 9 (2020)
Publisher Information: BMJ Publishing Group, 2020.
Publication Year: 2020
Collection: LCC:Medicine
Subject Terms: Medicine
More Details: Introduction This protocol describes an observational study which set out to assess whether frailty and/or multimorbidity correlates with short-term and medium-term outcomes in patients diagnosed with COVID-19 in a European, multicentre setting.Methods and analysis Over a 3-month period we aim to recruit a minimum of 500 patients across 10 hospital sites, collecting baseline data including: patient demographics; presence of comorbidities; relevant blood tests on admission; prescription of ACE inhibitors/angiotensin receptor blockers/non-steroidal anti-inflammatory drugs/immunosuppressants; smoking status; Clinical Frailty Score (CFS); length of hospital stay; mortality and readmission. All patients receiving inpatient hospital care >18 years who receive a diagnosis of COVID-19 are eligible for inclusion. Long-term follow-up at 6 and 12 months is planned. This will assess frailty, quality of life and medical complications.Our primary analysis will be short-term and long-term mortality by CFS, adjusted for age (18–64, 65–80 and >80) and gender. We will carry out a secondary analysis of the primary outcome by including additional clinical mediators which are determined statistically important using a likelihood ratio test. All analyses will be presented as crude and adjusted HR and OR with associated 95% CIs and p values.Ethics and dissemination This study has been registered, reviewed and approved by the following: Health Research Authority (20/HRA1898); Ethics Committee of Hospital Policlinico Modena, Italy (369/2020/OSS/AOUMO); Health and Care Research Permissions Service, Wales; and NHS Research Scotland Permissions Co-ordinating Centre, Scotland. All participating units obtained approval from their local Research and Development department consistent with the guidance from their relevant national organisation.Data will be reported as a whole cohort. This project will be submitted for presentation at a national or international surgical and geriatric conference. Manuscript(s) will be prepared following the close of the project.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2044-6055
Relation: https://bmjopen.bmj.com/content/10/9/e040569.full; https://doaj.org/toc/2044-6055
DOI: 10.1136/bmjopen-2020-040569
Access URL: https://doaj.org/article/fa9813ffb3f24eedafed8de02fa13f5a
Accession Number: edsdoj.fa9813ffb3f24eedafed8de02fa13f5a
Database: Directory of Open Access Journals
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edsdoj&genre=article&issn=20446055&ISBN=&volume=10&issue=9&date=20200901&spage=&pages=&title=BMJ Open&atitle=Study%20protocol%20for%20the%20COPE%20study%3A%20COVID-19%20in%20Older%20PEople%3A%20the%20influence%20of%20frailty%20and%20multimorbidity%20on%20survival.%20A%20multicentre%2C%20European%20observational%20study&aulast=Thomas%20Lee&id=DOI:10.1136/bmjopen-2020-040569
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
  – Url: https://doaj.org/article/fa9813ffb3f24eedafed8de02fa13f5a
    Name: EDS - DOAJ (s8985755)
    Category: fullText
    Text: View record from DOAJ
    MouseOverText: View record from DOAJ
Header DbId: edsdoj
DbLabel: Directory of Open Access Journals
An: edsdoj.fa9813ffb3f24eedafed8de02fa13f5a
RelevancyScore: 918
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 917.722778320313
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Study protocol for the COPE study: COVID-19 in Older PEople: the influence of frailty and multimorbidity on survival. A multicentre, European observational study
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Thomas+Lee%22">Thomas Lee</searchLink><br /><searchLink fieldCode="AR" term="%22Sandeep+Singh%22">Sandeep Singh</searchLink><br /><searchLink fieldCode="AR" term="%22Phyo+Kyaw+Myint%22">Phyo Kyaw Myint</searchLink><br /><searchLink fieldCode="AR" term="%22Sheila+Jones%22">Sheila Jones</searchLink><br /><searchLink fieldCode="AR" term="%22Ben+Carter%22">Ben Carter</searchLink><br /><searchLink fieldCode="AR" term="%22Susan+Moug%22">Susan Moug</searchLink><br /><searchLink fieldCode="AR" term="%22Terry+Quinn%22">Terry Quinn</searchLink><br /><searchLink fieldCode="AR" term="%22Michael+Thomas%22">Michael Thomas</searchLink><br /><searchLink fieldCode="AR" term="%22Emma+Bhatti%22">Emma Bhatti</searchLink><br /><searchLink fieldCode="AR" term="%22Angeline+Price%22">Angeline Price</searchLink><br /><searchLink fieldCode="AR" term="%22Fenella+Barlow-Pay%22">Fenella Barlow-Pay</searchLink><br /><searchLink fieldCode="AR" term="%22Siobhan+Duffy%22">Siobhan Duffy</searchLink><br /><searchLink fieldCode="AR" term="%22Lyndsay+Pearce%22">Lyndsay Pearce</searchLink><br /><searchLink fieldCode="AR" term="%22Arturo+Vilches-Moraga%22">Arturo Vilches-Moraga</searchLink><br /><searchLink fieldCode="AR" term="%22Michael+Stechman%22">Michael Stechman</searchLink><br /><searchLink fieldCode="AR" term="%22Philip+Braude%22">Philip Braude</searchLink><br /><searchLink fieldCode="AR" term="%22Emma+Mitchell%22">Emma Mitchell</searchLink><br /><searchLink fieldCode="AR" term="%22Alessia+Verduri%22">Alessia Verduri</searchLink><br /><searchLink fieldCode="AR" term="%22Kathryn+McCarthy%22">Kathryn McCarthy</searchLink><br /><searchLink fieldCode="AR" term="%22Jonathan+Hewitt%22">Jonathan Hewitt</searchLink><br /><searchLink fieldCode="AR" term="%22Charlotte+Davey%22">Charlotte Davey</searchLink><br /><searchLink fieldCode="AR" term="%22Kiah+Lunstone%22">Kiah Lunstone</searchLink><br /><searchLink fieldCode="AR" term="%22Alice+Cavenagh%22">Alice Cavenagh</searchLink><br /><searchLink fieldCode="AR" term="%22Charlotte+Silver%22">Charlotte Silver</searchLink><br /><searchLink fieldCode="AR" term="%22Thomas+Telford%22">Thomas Telford</searchLink><br /><searchLink fieldCode="AR" term="%22Rebecca+Simmons%22">Rebecca Simmons</searchLink><br /><searchLink fieldCode="AR" term="%22Dolcie+Paxton%22">Dolcie Paxton</searchLink><br /><searchLink fieldCode="AR" term="%22Francis+Rickard%22">Francis Rickard</searchLink><br /><searchLink fieldCode="AR" term="%22Mark+Holloway%22">Mark Holloway</searchLink><br /><searchLink fieldCode="AR" term="%22James+Hesford%22">James Hesford</searchLink><br /><searchLink fieldCode="AR" term="%22Tarik+Jichi%22">Tarik Jichi</searchLink><br /><searchLink fieldCode="AR" term="%22Norman+Galbraith%22">Norman Galbraith</searchLink><br /><searchLink fieldCode="AR" term="%22Jenny+Edwards%22">Jenny Edwards</searchLink><br /><searchLink fieldCode="AR" term="%22Carly+Bisset%22">Carly Bisset</searchLink><br /><searchLink fieldCode="AR" term="%22Ross+Alexander%22">Ross Alexander</searchLink><br /><searchLink fieldCode="AR" term="%22Abigail+Ingham%22">Abigail Ingham</searchLink><br /><searchLink fieldCode="AR" term="%22Roxanna+Short%22">Roxanna Short</searchLink><br /><searchLink fieldCode="AR" term="%22Aine+McGovern%22">Aine McGovern</searchLink><br /><searchLink fieldCode="AR" term="%22Jemima+Collins%22">Jemima Collins</searchLink><br /><searchLink fieldCode="AR" term="%22Eilidh+Bruce%22">Eilidh Bruce</searchLink><br /><searchLink fieldCode="AR" term="%22Alice+Einarsson%22">Alice Einarsson</searchLink><br /><searchLink fieldCode="AR" term="%22Enrico+Clini%22">Enrico Clini</searchLink><br /><searchLink fieldCode="AR" term="%22Giovanni+Guaraldi%22">Giovanni Guaraldi</searchLink><br /><searchLink fieldCode="AR" term="%22Madeline+Garcia%22">Madeline Garcia</searchLink><br /><searchLink fieldCode="AR" term="%22Shefali+Sangani%22">Shefali Sangani</searchLink><br /><searchLink fieldCode="AR" term="%22Thomas+Kneen%22">Thomas Kneen</searchLink><br /><searchLink fieldCode="AR" term="%22George+Kyriakopoulos%22">George Kyriakopoulos</searchLink><br /><searchLink fieldCode="AR" term="%22Denise+Tan%22">Denise Tan</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: BMJ Open, Vol 10, Iss 9 (2020)
– Name: Publisher
  Label: Publisher Information
  Group: PubInfo
  Data: BMJ Publishing Group, 2020.
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2020
– Name: Subset
  Label: Collection
  Group: HoldingsInfo
  Data: LCC:Medicine
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Medicine%22">Medicine</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Introduction This protocol describes an observational study which set out to assess whether frailty and/or multimorbidity correlates with short-term and medium-term outcomes in patients diagnosed with COVID-19 in a European, multicentre setting.Methods and analysis Over a 3-month period we aim to recruit a minimum of 500 patients across 10 hospital sites, collecting baseline data including: patient demographics; presence of comorbidities; relevant blood tests on admission; prescription of ACE inhibitors/angiotensin receptor blockers/non-steroidal anti-inflammatory drugs/immunosuppressants; smoking status; Clinical Frailty Score (CFS); length of hospital stay; mortality and readmission. All patients receiving inpatient hospital care >18 years who receive a diagnosis of COVID-19 are eligible for inclusion. Long-term follow-up at 6 and 12 months is planned. This will assess frailty, quality of life and medical complications.Our primary analysis will be short-term and long-term mortality by CFS, adjusted for age (18–64, 65–80 and >80) and gender. We will carry out a secondary analysis of the primary outcome by including additional clinical mediators which are determined statistically important using a likelihood ratio test. All analyses will be presented as crude and adjusted HR and OR with associated 95% CIs and p values.Ethics and dissemination This study has been registered, reviewed and approved by the following: Health Research Authority (20/HRA1898); Ethics Committee of Hospital Policlinico Modena, Italy (369/2020/OSS/AOUMO); Health and Care Research Permissions Service, Wales; and NHS Research Scotland Permissions Co-ordinating Centre, Scotland. All participating units obtained approval from their local Research and Development department consistent with the guidance from their relevant national organisation.Data will be reported as a whole cohort. This project will be submitted for presentation at a national or international surgical and geriatric conference. Manuscript(s) will be prepared following the close of the project.
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: article
– Name: Format
  Label: File Description
  Group: SrcInfo
  Data: electronic resource
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: ISSN
  Label: ISSN
  Group: ISSN
  Data: 2044-6055
– Name: NoteTitleSource
  Label: Relation
  Group: SrcInfo
  Data: https://bmjopen.bmj.com/content/10/9/e040569.full; https://doaj.org/toc/2044-6055
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1136/bmjopen-2020-040569
– Name: URL
  Label: Access URL
  Group: URL
  Data: <link linkTarget="URL" linkTerm="https://doaj.org/article/fa9813ffb3f24eedafed8de02fa13f5a" linkWindow="_blank">https://doaj.org/article/fa9813ffb3f24eedafed8de02fa13f5a</link>
– Name: AN
  Label: Accession Number
  Group: ID
  Data: edsdoj.fa9813ffb3f24eedafed8de02fa13f5a
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsdoj&AN=edsdoj.fa9813ffb3f24eedafed8de02fa13f5a
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1136/bmjopen-2020-040569
    Languages:
      – Text: English
    Subjects:
      – SubjectFull: Medicine
        Type: general
    Titles:
      – TitleFull: Study protocol for the COPE study: COVID-19 in Older PEople: the influence of frailty and multimorbidity on survival. A multicentre, European observational study
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Thomas Lee
      – PersonEntity:
          Name:
            NameFull: Sandeep Singh
      – PersonEntity:
          Name:
            NameFull: Phyo Kyaw Myint
      – PersonEntity:
          Name:
            NameFull: Sheila Jones
      – PersonEntity:
          Name:
            NameFull: Ben Carter
      – PersonEntity:
          Name:
            NameFull: Susan Moug
      – PersonEntity:
          Name:
            NameFull: Terry Quinn
      – PersonEntity:
          Name:
            NameFull: Michael Thomas
      – PersonEntity:
          Name:
            NameFull: Emma Bhatti
      – PersonEntity:
          Name:
            NameFull: Angeline Price
      – PersonEntity:
          Name:
            NameFull: Fenella Barlow-Pay
      – PersonEntity:
          Name:
            NameFull: Siobhan Duffy
      – PersonEntity:
          Name:
            NameFull: Lyndsay Pearce
      – PersonEntity:
          Name:
            NameFull: Arturo Vilches-Moraga
      – PersonEntity:
          Name:
            NameFull: Michael Stechman
      – PersonEntity:
          Name:
            NameFull: Philip Braude
      – PersonEntity:
          Name:
            NameFull: Emma Mitchell
      – PersonEntity:
          Name:
            NameFull: Alessia Verduri
      – PersonEntity:
          Name:
            NameFull: Kathryn McCarthy
      – PersonEntity:
          Name:
            NameFull: Jonathan Hewitt
      – PersonEntity:
          Name:
            NameFull: Charlotte Davey
      – PersonEntity:
          Name:
            NameFull: Kiah Lunstone
      – PersonEntity:
          Name:
            NameFull: Alice Cavenagh
      – PersonEntity:
          Name:
            NameFull: Charlotte Silver
      – PersonEntity:
          Name:
            NameFull: Thomas Telford
      – PersonEntity:
          Name:
            NameFull: Rebecca Simmons
      – PersonEntity:
          Name:
            NameFull: Dolcie Paxton
      – PersonEntity:
          Name:
            NameFull: Francis Rickard
      – PersonEntity:
          Name:
            NameFull: Mark Holloway
      – PersonEntity:
          Name:
            NameFull: James Hesford
      – PersonEntity:
          Name:
            NameFull: Tarik Jichi
      – PersonEntity:
          Name:
            NameFull: Norman Galbraith
      – PersonEntity:
          Name:
            NameFull: Jenny Edwards
      – PersonEntity:
          Name:
            NameFull: Carly Bisset
      – PersonEntity:
          Name:
            NameFull: Ross Alexander
      – PersonEntity:
          Name:
            NameFull: Abigail Ingham
      – PersonEntity:
          Name:
            NameFull: Roxanna Short
      – PersonEntity:
          Name:
            NameFull: Aine McGovern
      – PersonEntity:
          Name:
            NameFull: Jemima Collins
      – PersonEntity:
          Name:
            NameFull: Eilidh Bruce
      – PersonEntity:
          Name:
            NameFull: Alice Einarsson
      – PersonEntity:
          Name:
            NameFull: Enrico Clini
      – PersonEntity:
          Name:
            NameFull: Giovanni Guaraldi
      – PersonEntity:
          Name:
            NameFull: Madeline Garcia
      – PersonEntity:
          Name:
            NameFull: Shefali Sangani
      – PersonEntity:
          Name:
            NameFull: Thomas Kneen
      – PersonEntity:
          Name:
            NameFull: George Kyriakopoulos
      – PersonEntity:
          Name:
            NameFull: Denise Tan
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 09
              Type: published
              Y: 2020
          Identifiers:
            – Type: issn-print
              Value: 20446055
          Numbering:
            – Type: volume
              Value: 10
            – Type: issue
              Value: 9
          Titles:
            – TitleFull: BMJ Open
              Type: main
ResultId 1