CD1 VASCULAR ADAPTATION TO EXTREME CONDITIONS: THE ROLE OF HYPOXIA

Bibliographic Details
Title:	CD1 VASCULAR ADAPTATION TO EXTREME CONDITIONS: THE ROLE OF HYPOXIA
Authors:	Rosa Maria Bruno, Lorenzo Ghiadoni, Lorenza Pratali
Source:	Artery Research, Vol 12 (2015)
Publisher Information:	BMC, 2015.
Publication Year:	2015
Collection:	LCC:Specialties of internal medicine LCC:Diseases of the circulatory (Cardiovascular) system
Subject Terms:	Specialties of internal medicine, RC581-951, Diseases of the circulatory (Cardiovascular) system, RC666-701
More Details:	The study of vascular adaptation to extreme conditions, and in particular to hypoxia, represents a unique opportunity in cardiovascular physiology, with relevant translational implications. First, it has crucial clinical consequences for about 140 million people worldwide living at high altitude and chronically exposed to hypobaric hypoxia. Second, an increasing number of lowlanders are exposed to high altitude for recreational or working purposes, including aged, diseased individuals: in these cases, hypoxia could be a trigger for acute cardiovascular events. Finally, hypoxia plays a major role in the pathogenesis of many diseases and chronic conditions, as respiratory (i.e. chronic obstructive pulmonary disease and obstructive sleep apnea syndrome) and cardiovascular disorders (i.e. heart failure, ischemic heart disease and cerebrovascular disease). Thus, results from field studies at high altitude might be important for a deeper understanding of their pathophysiology. This review is aimed at summarizing the main findings in the field of chronic and acute vascular adaptation to hypoxia, focusing on the role of nitric oxide (NO) and endothelial function, as well as large artery behavior.
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	1876-4401
Relation:	https://www.atlantis-press.com/article/125930547/view; https://doaj.org/toc/1876-4401
DOI:	10.1016/j.artres.2015.10.188
Access URL:	https://doaj.org/article/f8f2e4d96c02401ba67705f64dfd24ac
Accession Number:	edsdoj.f8f2e4d96c02401ba67705f64dfd24ac
Database:	Directory of Open Access Journals

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RecordInfo	BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.artres.2015.10.188 Languages: – Text: English Subjects: – SubjectFull: Specialties of internal medicine Type: general – SubjectFull: RC581-951 Type: general – SubjectFull: Diseases of the circulatory (Cardiovascular) system Type: general – SubjectFull: RC666-701 Type: general Titles: – TitleFull: CD1 VASCULAR ADAPTATION TO EXTREME CONDITIONS: THE ROLE OF HYPOXIA Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Rosa Maria Bruno – PersonEntity: Name: NameFull: Lorenzo Ghiadoni – PersonEntity: Name: NameFull: Lorenza Pratali IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Type: published Y: 2015 Identifiers: – Type: issn-print Value: 18764401 Numbering: – Type: volume Value: 12 Titles: – TitleFull: Artery Research Type: main
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