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Low-Dose Anti-Thymocyte Globulin Plus Low-Dose Posttransplant Cyclophosphamide as an Effective Regimen for Prophylaxis of Graft Host Disease After Haploidentical Peripheral Blood Stem Cell Transplantation With Maternal/Collateral Related Donors

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Title: Low-Dose Anti-Thymocyte Globulin Plus Low-Dose Posttransplant Cyclophosphamide as an Effective Regimen for Prophylaxis of Graft Host Disease After Haploidentical Peripheral Blood Stem Cell Transplantation With Maternal/Collateral Related Donors
Authors: Ting Li, Qiaomei He, Jun Yang, Yu Cai, Chongmei Huang, Xiaowei Xu, Huiying Qiu, Jiahua Niu, Kun Zhou, Yin Zhang, Xinxin Xia, Yu Wei, Chang Shen, Xueying Ding, Yin Tong, Liping Wan, Xianmin Song
Source: Cell Transplantation, Vol 31 (2022)
Publisher Information: SAGE Publishing, 2022.
Publication Year: 2022
Collection: LCC:Medicine
Subject Terms: Medicine
More Details: Maternal and collateral donors were associated with a higher incidence of graft- versus -host disease (GvHD) after haploidentical hematopoietic stem cell transplantation (haplo-HSCT). A more effective regimen for GvHD prophylaxis after haplo-HSCT with maternal/collateral donors needed to be explored. A retrospective study was performed on 62 patients after haploidentical peripheral blood stem cell transplantation (haplo-PBSCT) with maternal/collateral donors, which included 35 patients with low-dose antithymocyte globulin (ATG) plus low-dose posttransplant cyclophosphamide-based (low-dose ATG/PTCy-based) and 27 with ATG-based regimens for GvHD prophylaxis. The 180-day cumulative incidences (CIs) of grades II-IV and III-IV acute GvHD (aGvHD) were 17.7% and 6.8% in low-dose ATG/PTCy-based group, which were significantly lower than that in ATG-based group (55.4% and 31.9%) ( P = 0.003 for grade II-IV and P = 0.007 for III-IV aGvHD). In low-dose ATG/PTCy-based group, the 1-year overall survival (OS) and relapse-free survival (RFS) were 80.0%and 80.4%, which were higher than that in ATG-based group with OS of 59.4% and RFS of 62.0%. In multivariate analysis, the low-dose ATG/PTCy-based regimen significantly reduced the risk of grade II-IV (HR = 0.357; P = 0.049) and grade III-IV aGvHD (HR = 0.190; P = 0.046) as an independent risk factor. The results suggested that the low-dose ATG/PTCy-based regimen could effectively prevent the occurrence of aGvHD after haplo-PBSCT with maternal/collateral donors compared with the ATG-based regimen.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1555-3892
09636897
Relation: https://doaj.org/toc/1555-3892
DOI: 10.1177/09636897221139103
Access URL: https://doaj.org/article/ef8218d2c4834898b9ff84f6b5e48bed
Accession Number: edsdoj.f8218d2c4834898b9ff84f6b5e48bed
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  Data: Low-Dose Anti-Thymocyte Globulin Plus Low-Dose Posttransplant Cyclophosphamide as an Effective Regimen for Prophylaxis of Graft Host Disease After Haploidentical Peripheral Blood Stem Cell Transplantation With Maternal/Collateral Related Donors
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  Data: <searchLink fieldCode="AR" term="%22Ting+Li%22">Ting Li</searchLink><br /><searchLink fieldCode="AR" term="%22Qiaomei+He%22">Qiaomei He</searchLink><br /><searchLink fieldCode="AR" term="%22Jun+Yang%22">Jun Yang</searchLink><br /><searchLink fieldCode="AR" term="%22Yu+Cai%22">Yu Cai</searchLink><br /><searchLink fieldCode="AR" term="%22Chongmei+Huang%22">Chongmei Huang</searchLink><br /><searchLink fieldCode="AR" term="%22Xiaowei+Xu%22">Xiaowei Xu</searchLink><br /><searchLink fieldCode="AR" term="%22Huiying+Qiu%22">Huiying Qiu</searchLink><br /><searchLink fieldCode="AR" term="%22Jiahua+Niu%22">Jiahua Niu</searchLink><br /><searchLink fieldCode="AR" term="%22Kun+Zhou%22">Kun Zhou</searchLink><br /><searchLink fieldCode="AR" term="%22Yin+Zhang%22">Yin Zhang</searchLink><br /><searchLink fieldCode="AR" term="%22Xinxin+Xia%22">Xinxin Xia</searchLink><br /><searchLink fieldCode="AR" term="%22Yu+Wei%22">Yu Wei</searchLink><br /><searchLink fieldCode="AR" term="%22Chang+Shen%22">Chang Shen</searchLink><br /><searchLink fieldCode="AR" term="%22Xueying+Ding%22">Xueying Ding</searchLink><br /><searchLink fieldCode="AR" term="%22Yin+Tong%22">Yin Tong</searchLink><br /><searchLink fieldCode="AR" term="%22Liping+Wan%22">Liping Wan</searchLink><br /><searchLink fieldCode="AR" term="%22Xianmin+Song%22">Xianmin Song</searchLink>
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  Data: Cell Transplantation, Vol 31 (2022)
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  Data: Maternal and collateral donors were associated with a higher incidence of graft- versus -host disease (GvHD) after haploidentical hematopoietic stem cell transplantation (haplo-HSCT). A more effective regimen for GvHD prophylaxis after haplo-HSCT with maternal/collateral donors needed to be explored. A retrospective study was performed on 62 patients after haploidentical peripheral blood stem cell transplantation (haplo-PBSCT) with maternal/collateral donors, which included 35 patients with low-dose antithymocyte globulin (ATG) plus low-dose posttransplant cyclophosphamide-based (low-dose ATG/PTCy-based) and 27 with ATG-based regimens for GvHD prophylaxis. The 180-day cumulative incidences (CIs) of grades II-IV and III-IV acute GvHD (aGvHD) were 17.7% and 6.8% in low-dose ATG/PTCy-based group, which were significantly lower than that in ATG-based group (55.4% and 31.9%) ( P = 0.003 for grade II-IV and P = 0.007 for III-IV aGvHD). In low-dose ATG/PTCy-based group, the 1-year overall survival (OS) and relapse-free survival (RFS) were 80.0%and 80.4%, which were higher than that in ATG-based group with OS of 59.4% and RFS of 62.0%. In multivariate analysis, the low-dose ATG/PTCy-based regimen significantly reduced the risk of grade II-IV (HR = 0.357; P = 0.049) and grade III-IV aGvHD (HR = 0.190; P = 0.046) as an independent risk factor. The results suggested that the low-dose ATG/PTCy-based regimen could effectively prevent the occurrence of aGvHD after haplo-PBSCT with maternal/collateral donors compared with the ATG-based regimen.
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