The Paradoxical Role of NKG2D in Cancer Immunity

Bibliographic Details
Title:	The Paradoxical Role of NKG2D in Cancer Immunity
Authors:	Sam Sheppard, Amir Ferry, Joana Guedes, Nadia Guerra
Source:	Frontiers in Immunology, Vol 9 (2018)
Publisher Information:	Frontiers Media S.A., 2018.
Publication Year:	2018
Collection:	LCC:Immunologic diseases. Allergy
Subject Terms:	NKG2D, cancer, hepatocellular carcinoma, inflammation, CD8+ T cells, natural killer cells, Immunologic diseases. Allergy, RC581-607
More Details:	The activating receptor NKG2D and its ligands are recognized as a potent immune axis that controls tumor growth and microbial infections. With regards to cancer surveillance, various studies have demonstrated the antitumor function mediated by NKG2D on natural killer cells and on conventional and unconventional T cells. The use of NKG2D-deficient mice established the importance of NKG2D in delaying tumor development in transgenic mouse models of cancer. However, we recently demonstrated an unexpected, flip side to this coin, the ability for NKG2D to contribute to tumor growth in a model of inflammation-driven liver cancer. With a focus on the liver, here, we review current knowledge of NKG2D-mediated tumor surveillance and discuss evidence supporting a dual role for NKG2D in cancer immunity. We postulate that in certain advanced cancers, expression of ligands for NKG2D can drive cancer progression rather than rejection. We propose that the nature of the microenvironment within and surrounding tumors impacts the outcome of NKG2D activation. In a form of autoimmune attack, NKG2D promotes tissue damage, mostly in the inflamed tissue adjacent to the tumor, facilitating tumor progression while being ineffective at rejecting transformed cells in the tumor bed.
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	1664-3224
Relation:	https://www.frontiersin.org/article/10.3389/fimmu.2018.01808/full; https://doaj.org/toc/1664-3224
DOI:	10.3389/fimmu.2018.01808
Access URL:	https://doaj.org/article/f7a8c0970b5746d5b6894f1432d6d4d5
Accession Number:	edsdoj.f7a8c0970b5746d5b6894f1432d6d4d5
Database:	Directory of Open Access Journals

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Items	– Name: Title Label: Title Group: Ti Data: The Paradoxical Role of NKG2D in Cancer Immunity – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Sam+Sheppard%22">Sam Sheppard</searchLink><br /><searchLink fieldCode="AR" term="%22Amir+Ferry%22">Amir Ferry</searchLink><br /><searchLink fieldCode="AR" term="%22Joana+Guedes%22">Joana Guedes</searchLink><br /><searchLink fieldCode="AR" term="%22Nadia+Guerra%22">Nadia Guerra</searchLink> – Name: TitleSource Label: Source Group: Src Data: Frontiers in Immunology, Vol 9 (2018) – Name: Publisher Label: Publisher Information Group: PubInfo Data: Frontiers Media S.A., 2018. – Name: DatePubCY Label: Publication Year Group: Date Data: 2018 – Name: Subset Label: Collection Group: HoldingsInfo Data: LCC:Immunologic diseases. Allergy – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22NKG2D%22">NKG2D</searchLink><br /><searchLink fieldCode="DE" term="%22cancer%22">cancer</searchLink><br /><searchLink fieldCode="DE" term="%22hepatocellular+carcinoma%22">hepatocellular carcinoma</searchLink><br /><searchLink fieldCode="DE" term="%22inflammation%22">inflammation</searchLink><br /><searchLink fieldCode="DE" term="%22CD8%2B+T+cells%22">CD8+ T cells</searchLink><br /><searchLink fieldCode="DE" term="%22natural+killer+cells%22">natural killer cells</searchLink><br /><searchLink fieldCode="DE" term="%22Immunologic+diseases%2E+Allergy%22">Immunologic diseases. Allergy</searchLink><br /><searchLink fieldCode="DE" term="%22RC581-607%22">RC581-607</searchLink> – Name: Abstract Label: Description Group: Ab Data: The activating receptor NKG2D and its ligands are recognized as a potent immune axis that controls tumor growth and microbial infections. With regards to cancer surveillance, various studies have demonstrated the antitumor function mediated by NKG2D on natural killer cells and on conventional and unconventional T cells. The use of NKG2D-deficient mice established the importance of NKG2D in delaying tumor development in transgenic mouse models of cancer. However, we recently demonstrated an unexpected, flip side to this coin, the ability for NKG2D to contribute to tumor growth in a model of inflammation-driven liver cancer. With a focus on the liver, here, we review current knowledge of NKG2D-mediated tumor surveillance and discuss evidence supporting a dual role for NKG2D in cancer immunity. We postulate that in certain advanced cancers, expression of ligands for NKG2D can drive cancer progression rather than rejection. We propose that the nature of the microenvironment within and surrounding tumors impacts the outcome of NKG2D activation. In a form of autoimmune attack, NKG2D promotes tissue damage, mostly in the inflamed tissue adjacent to the tumor, facilitating tumor progression while being ineffective at rejecting transformed cells in the tumor bed. – Name: TypeDocument Label: Document Type Group: TypDoc Data: article – Name: Format Label: File Description Group: SrcInfo Data: electronic resource – Name: Language Label: Language Group: Lang Data: English – Name: ISSN Label: ISSN Group: ISSN Data: 1664-3224 – Name: NoteTitleSource Label: Relation Group: SrcInfo Data: https://www.frontiersin.org/article/10.3389/fimmu.2018.01808/full; https://doaj.org/toc/1664-3224 – Name: DOI Label: DOI Group: ID Data: 10.3389/fimmu.2018.01808 – Name: URL Label: Access URL Group: URL Data: <link linkTarget="URL" linkTerm="https://doaj.org/article/f7a8c0970b5746d5b6894f1432d6d4d5" linkWindow="_blank">https://doaj.org/article/f7a8c0970b5746d5b6894f1432d6d4d5</link> – Name: AN Label: Accession Number Group: ID Data: edsdoj.f7a8c0970b5746d5b6894f1432d6d4d5
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RecordInfo	BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3389/fimmu.2018.01808 Languages: – Text: English Subjects: – SubjectFull: NKG2D Type: general – SubjectFull: cancer Type: general – SubjectFull: hepatocellular carcinoma Type: general – SubjectFull: inflammation Type: general – SubjectFull: CD8+ T cells Type: general – SubjectFull: natural killer cells Type: general – SubjectFull: Immunologic diseases. Allergy Type: general – SubjectFull: RC581-607 Type: general Titles: – TitleFull: The Paradoxical Role of NKG2D in Cancer Immunity Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Sam Sheppard – PersonEntity: Name: NameFull: Amir Ferry – PersonEntity: Name: NameFull: Joana Guedes – PersonEntity: Name: NameFull: Nadia Guerra IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Type: published Y: 2018 Identifiers: – Type: issn-print Value: 16643224 Numbering: – Type: volume Value: 9 Titles: – TitleFull: Frontiers in Immunology Type: main
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