Academic Journal
Weaker SARS-CoV-2 vaccine responses in nonalcoholic fatty liver disease with advanced liver fibrosis
| Title: | Weaker SARS-CoV-2 vaccine responses in nonalcoholic fatty liver disease with advanced liver fibrosis |
|---|---|
| Authors: | David Hakimian, Johnny Amer, Alaa Jammal, Asher Shafrir, Yael Milgrom, Mohammad Masarowah, Wadi Hazou, Yuval Ishay, Ashraf Imam, Adi Francis, Abed Khalaileh, Rifaat Safadi |
| Source: | Vaccine: X, Vol 15, Iss , Pp 100359- (2023) |
| Publisher Information: | Elsevier, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Immunologic diseases. Allergy |
| Subject Terms: | Pfizer's mRNA SARS-CoV-2 vaccine, Serum SARS-CoV-2 spike immunoglobulins, NAS score, Liver fibrosis stage, Fibroscan, Immunologic diseases. Allergy, RC581-607 |
| More Details: | Background: SARS-CoV-2 vaccine responses that could harbor potential risks to chronic liver diseased patients. Aims: To assess immune response following Pfizer's SARS-CoV-2 vaccine in patients with different liver fibrosis severities of nonalcoholic fatty liver disease (NAFLD). Methods: Clinical and histological (NAS-score and fibrosis stage) characteristics of NAFLD patients before vaccine were correlated with serologic vaccine responses of two doses of the BNT162b2. Serum SARS-CoV-2 spike immunoglobulins (anti-S) were assessed on day seven following immunization (Liaison assay). Results: The mean-age of patients (n = 157) was 56.9 ± 13.2 years (46.5 % males). 94.8 % had a positive response (anti-S levels ≥ 19 AU/ml). The anti-S cutoff of 200 AU/ml used to separate strong vs. weak responses. A strong response (anti-S titers ≥ 200 AU/ml) was observed in 93/157 (59.2 %) patients with a mean-age of 53.1 ± 13.8 years (45.2 % males). A weak response (anti-S titers |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2590-1362 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2590136223001006; https://doaj.org/toc/2590-1362 |
| DOI: | 10.1016/j.jvacx.2023.100359 |
| Access URL: | https://doaj.org/article/af4b55d4ed4142b8ae2d7851c624af9a |
| Accession Number: | edsdoj.f4b55d4ed4142b8ae2d7851c624af9a |
| Database: | Directory of Open Access Journals |
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